Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-5-31
pubmed:abstractText
The Michaelis-Menten inhibitory constants (Kis) and the concentrations required for 50% inhibition of the Plasmodium falciparum dihydropteroate synthetase were determined for six sulfa drugs. These drugs inhibited the in vitro growth of P. falciparum (50% lethal concentration) at concentrations of 30 to 500 nM; these concentrations were 100 to 1,000 times lower than the concentrations required for 50% inhibition and Kis (6 to 500 microM). The uptake of p-aminobenzoic acid was not inhibited by the sulfa drugs. However, infected erythrocytes took up more labeled sulfamethoxazole than did uninfected erythrocytes. Thus, the concentration of sulfa drugs by malaria parasites may explain how sulfa drugs inhibit in vitro growth of parasites through the inhibition of dihydropteroate synthetase.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-14209957, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-2203302, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-2873508, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-3276904, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-3329779, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-3545765, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-3885030, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-4354403, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-4597736, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-4602912, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-6348944, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-6375404, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-6385738, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-6754119, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-7374502, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-781840, http://linkedlifedata.com/resource/pubmed/commentcorrection/2024960-942051
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-71
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs.
pubmed:affiliation
Department of Microbiology, City University of New York Medical School, New York 10031.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't