Linked Life Data

2024491

Source:http://linkedlifedata.com/resource/pubmed/id/2024491

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-6-6
pubmed:abstractText
During infection by the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV), synthesis of host proteins in IPLB-Sf-21 cells is inhibited. We report here that cytochalasin D (CD), a drug that specifically interacts with actin, behaved as an antagonist in the virus-mediated shutdown of host proteins actin and tubulin. In uninfected cells, CD caused an increase in actin synthesis but had no apparent effect on tubulin synthesis. In infected cells, CD similarly enhanced actin synthesis early in infection and delayed the virus shutoff of actin synthesis by 14 hr. The shutoff of tubulin synthesis was delayed by 8 hr. Addition of CD to infected cells after host protein synthesis ceased resulted in an induction of actin synthesis reversing viral inhibitory effects. Similarly, the removal of CD resulted in virus-induced inhibition of actin synthesis. Treatment of infected cells with CD caused a delay in the onset and/or shutoff of at least five viral proteins and inhibited the amplification of polyhedrin synthesis by at least 8 hr.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:volume
182
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
626-34
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Autographa californica M nuclear polyhedrosis virus and cytochalasin D: antagonists in the regulation of protein synthesis.
pubmed:affiliation
Department of Entomology, University of California, Berkeley 94720.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.