Linked Life Data

20238421

Source:http://linkedlifedata.com/resource/pubmed/id/20238421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-3-18
pubmed:abstractText
Naive T-helper (Th) cells differentiate into distinct lineages including Th1, Th2, Th17 and regulatory T (Treg) cells. Each of these Th-lineages has specific functions in immune defense and T cell homeostasis. Th cell fate decisions and commitment are dependent on the kind and strength of T cell stimulation and the subsequent gene expression profiles. Our analysis targeted the identification of new regulatory transcription factor binding sites (TFBSs) in the promoter regions of up- and down-regulated genes in Treg cell differentiation and lineage maintenance. For this approach we compared different gene groups from global gene expression studies with background models of randomly selected genes to identify significantly overrepresented TFBSs. Results of our analysis suggest that Ets and IRF family members contribute to the regulation of the initial induction of Treg cells. Furthermore, we identified the overrepresented TFBS-pairs Runx-NFAT and GATA3-Foxp3 in Treg specific genes and Foxp3 dependent genes, respectively. Interestingly, previous studies have observed functional interactions of both TFBS-pairs in T cells. This study provides a starting point for further investigations to elucidate the transcriptional network in Treg cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0919-9454
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
84-94
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Prediction of regulatory transcription factors in T helper cell differentiation and maintenance.
pubmed:affiliation
Institute for Theoretical Biology, Humboldt University of Berlin, Invalidenstr. 43, 10115 Berlin, Germany. yuehien@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't