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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-4-6
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pubmed:abstractText |
Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI 27661,
http://linkedlifedata.com/resource/pubmed/grant/AI 27665,
http://linkedlifedata.com/resource/pubmed/grant/AI 46370,
http://linkedlifedata.com/resource/pubmed/grant/AI-69501,
http://linkedlifedata.com/resource/pubmed/grant/AI041534,
http://linkedlifedata.com/resource/pubmed/grant/AI069532,
http://linkedlifedata.com/resource/pubmed/grant/AI41530,
http://linkedlifedata.com/resource/pubmed/grant/AI41531,
http://linkedlifedata.com/resource/pubmed/grant/AI43638,
http://linkedlifedata.com/resource/pubmed/grant/M01RR00096,
http://linkedlifedata.com/resource/pubmed/grant/RR024143,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI041534-05,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI041534-06,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI041534-07,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI041534-08,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI041534-09
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-10737796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-11029005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-11877476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-11986671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-1503611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-15365095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-15365096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-16941337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-17147468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-17599319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-18645523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-2595372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-9537934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235838-9952358
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1537-6613
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pubmed:author |
pubmed-author:AbergJudithJ,
pubmed-author:BalfourHenry HHHJr,
pubmed-author:BodenDanielD,
pubmed-author:ConradAnnA,
pubmed-author:HareC BradleyCB,
pubmed-author:HechtFrederick MFM,
pubmed-author:HoganChristineC,
pubmed-author:KalayjianRobert CRC,
pubmed-author:KilbyJ MichaelJM,
pubmed-author:LittleSusanS,
pubmed-author:MarkowitzMartinM,
pubmed-author:MildvanDonnaD,
pubmed-author:MohriHiroshiH,
pubmed-author:RichmanDouglasD,
pubmed-author:SchaferKimK,
pubmed-author:VaidaFlorinF
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1298-302
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20235838-Adult,
pubmed-meshheading:20235838-Anti-HIV Agents,
pubmed-meshheading:20235838-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:20235838-CD4 Lymphocyte Count,
pubmed-meshheading:20235838-Cyclosporine,
pubmed-meshheading:20235838-Drug Therapy, Combination,
pubmed-meshheading:20235838-Female,
pubmed-meshheading:20235838-HIV Infections,
pubmed-meshheading:20235838-HIV-1,
pubmed-meshheading:20235838-Humans,
pubmed-meshheading:20235838-Immunosuppressive Agents,
pubmed-meshheading:20235838-Male,
pubmed-meshheading:20235838-Viral Load
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pubmed:year |
2010
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pubmed:articleTitle |
The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.
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pubmed:affiliation |
Aaron Diamond AIDS Research Center, an affiliate of Rockefeller University, New York, New York, USA. mmarkowitz@adarc.org
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, N.I.H., Extramural
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