|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0336791,
umls-concept:C0441833,
umls-concept:C0679622,
umls-concept:C0682526,
umls-concept:C1522138,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1999270
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-3-18
|
|
pubmed:abstractText |
While powerful in silico tools are emerging for predicting drug targets and pathways, general in vitro tools for assessing such predictions are lacking. We present a novel in vitro method for distinguishing shared versus distinct drug pathways based on comparative cell growth inhibition profiles across a small panel of human lymphoblastoid cell lines (LCLs) from individual donors.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1744-8042
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
327-40
|
|
pubmed:meshHeading |
pubmed-meshheading:20235789-Antidepressive Agents,
pubmed-meshheading:20235789-Antineoplastic Agents,
pubmed-meshheading:20235789-Antipsychotic Agents,
pubmed-meshheading:20235789-Cell Line,
pubmed-meshheading:20235789-Cell Proliferation,
pubmed-meshheading:20235789-Chlorpheniramine,
pubmed-meshheading:20235789-Drug Evaluation, Preclinical,
pubmed-meshheading:20235789-Drug Resistance,
pubmed-meshheading:20235789-Humans,
pubmed-meshheading:20235789-Lymphocytes,
pubmed-meshheading:20235789-Metabolic Networks and Pathways,
pubmed-meshheading:20235789-Pharmacogenetics,
pubmed-meshheading:20235789-Serotonin Uptake Inhibitors,
pubmed-meshheading:20235789-Steroids
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways.
|
|
pubmed:affiliation |
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
