20233183

Source:http://linkedlifedata.com/resource/pubmed/id/20233183

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0028426, umls-concept:C0205210, umls-concept:C0205976, umls-concept:C1176140, umls-concept:C1332829, umls-concept:C1704675, umls-concept:C2674784
pubmed:issue	2
pubmed:dateCreated	2010-3-17
pubmed:abstractText	To investigate the inhibition potential and kinetic information of noscapine to seven CYP isoforms and extrapolate in vivo noscapine-warfarin interaction magnitude from in vitro data.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/DA 012521, http://linkedlifedata.com/resource/pubmed/grant/P30 DA012393, http://linkedlifedata.com/resource/pubmed/grant/P50 DA018179
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7503323
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anticoagulants, http://linkedlifedata.com/resource/pubmed/chemical/Antitussive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/CYP2C9 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Noscapine, http://linkedlifedata.com/resource/pubmed/chemical/Warfarin
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1365-2125
pubmed:author	pubmed-author:FangZhong-ZeZZ, pubmed-author:GeGuang-BoGB, pubmed-author:HuoHongH, pubmed-author:LiangSi-ChengSC, pubmed-author:YangLingL, pubmed-author:ZhangYan-YanYY
pubmed:issnType	Electronic
pubmed:volume	69
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	193-9
pubmed:dateRevised	2011-7-22
pubmed:meshHeading	pubmed-meshheading:20233183-Adult, pubmed-meshheading:20233183-Anticoagulants, pubmed-meshheading:20233183-Antitussive Agents, pubmed-meshheading:20233183-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:20233183-Cytochrome P-450 CYP3A, pubmed-meshheading:20233183-Dose-Response Relationship, Drug, pubmed-meshheading:20233183-Drug Interactions, pubmed-meshheading:20233183-Humans, pubmed-meshheading:20233183-Male, pubmed-meshheading:20233183-Microsomes, Liver, pubmed-meshheading:20233183-Middle Aged, pubmed-meshheading:20233183-Models, Biological, pubmed-meshheading:20233183-Models, Chemical, pubmed-meshheading:20233183-Noscapine, pubmed-meshheading:20233183-Time Factors, pubmed-meshheading:20233183-Tissue Culture Techniques, pubmed-meshheading:20233183-Warfarin
pubmed:year	2010
pubmed:articleTitle	Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction.
pubmed:affiliation	Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural