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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2010-6-18
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pubmed:abstractText |
Complement receptor 2-negative (CR2/CD21(-)) B cells have been found enriched in patients with autoimmune diseases and in common variable immunodeficiency (CVID) patients who are prone to autoimmunity. However, the physiology of CD21(-/lo) B cells remains poorly characterized. We found that some rheumatoid arthritis (RA) patients also display an increased frequency of CD21(-/lo) B cells in their blood. A majority of CD21(-/lo) B cells from RA and CVID patients expressed germline autoreactive antibodies, which recognized nuclear and cytoplasmic structures. In addition, these B cells were unable to induce calcium flux, become activated, or proliferate in response to B-cell receptor and/or CD40 triggering, suggesting that these autoreactive B cells may be anergic. Moreover, gene array analyses of CD21(-/lo) B cells revealed molecules specifically expressed in these B cells and that are likely to induce their unresponsive stage. Thus, CD21(-/lo) B cells contain mostly autoreactive unresponsive clones, which express a specific set of molecules that may represent new biomarkers to identify anergic B cells in humans.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/ICOSLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL2RA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement 3d,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF13B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transmembrane Activator and CAML...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:BermanJessicaJ,
pubmed-author:BucknerJane HJH,
pubmed-author:Cunningham-RundlesCharlotteC,
pubmed-author:IsnardiIsabelleI,
pubmed-author:MeffreEricE,
pubmed-author:MenardLaurenceL,
pubmed-author:MeyersGretaG,
pubmed-author:NgYen-ShingYS,
pubmed-author:SaadounDavidD,
pubmed-author:SamuelsJonathanJ,
pubmed-author:SrdanovicIvaI
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5026-36
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20231422-Adult,
pubmed-meshheading:20231422-Antigens, CD,
pubmed-meshheading:20231422-Antigens, CD40,
pubmed-meshheading:20231422-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:20231422-Apoptosis,
pubmed-meshheading:20231422-Autoantibodies,
pubmed-meshheading:20231422-Autoimmune Diseases,
pubmed-meshheading:20231422-B-Lymphocytes,
pubmed-meshheading:20231422-Biological Markers,
pubmed-meshheading:20231422-Cell Division,
pubmed-meshheading:20231422-Clonal Anergy,
pubmed-meshheading:20231422-Female,
pubmed-meshheading:20231422-Gene Expression Profiling,
pubmed-meshheading:20231422-Humans,
pubmed-meshheading:20231422-Immunophenotyping,
pubmed-meshheading:20231422-Inducible T-Cell Co-Stimulator Ligand,
pubmed-meshheading:20231422-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:20231422-Lectins, C-Type,
pubmed-meshheading:20231422-Lymphocyte Activation,
pubmed-meshheading:20231422-Male,
pubmed-meshheading:20231422-Receptors, Complement 3d,
pubmed-meshheading:20231422-Receptors, IgE,
pubmed-meshheading:20231422-Transmembrane Activator and CAML Interactor Protein,
pubmed-meshheading:20231422-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones.
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pubmed:affiliation |
Laboratory of Molecular Immunology, Hospital for Special Surgery, New York, NY, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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