| pubmed-article:20228810 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C0560175 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C1180347 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C0887838 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C1412504 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C1419227 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C1422187 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C0005495 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C1706209 | lld:lifeskim |
| pubmed-article:20228810 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:20228810 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20228810 | pubmed:dateCreated | 2010-4-2 | lld:pubmed |
| pubmed-article:20228810 | pubmed:abstractText | Actin dynamics is a tightly regulated process involved in various cellular events including biogenesis of clathrin-coated, AP-1 (adaptor protein 1)-coated transport carriers connecting the trans-Golgi network (TGN) and the endocytic pathway. However, the mechanisms coordinating coat assembly, membrane and actin remodelling during post-TGN transport remain poorly understood. Here we show that the Arf1 (ADP-ribosylation factor 1) GTPase synchronizes the TGN association of clathrin-AP-1 coats and protein complexes comprising CYFIP (cytoplasmic fragile-X mental retardation interacting protein; Sra, PIR121), a clathrin heavy chain binding protein associated with mental retardation. The Rac1 GTPase and its exchange factor beta-PIX (PAK-interacting exchange factor) activate these complexes, allowing N-WASP-dependent and Arp2/3-dependent actin polymerization towards membranes, thus promoting tubule formation. These phenomena can be recapitulated with synthetic membranes. This protein-network-based mechanism facilitates the sequential coordination of Arf1-dependent membrane priming, through the recruitment of coats and CYFIP-containing complexes, and of Rac1-dependent actin polymerization, and provides complementary but independent levels of regulation during early stages of clathrin-AP1-coated carrier biogenesis. | lld:pubmed |
| pubmed-article:20228810 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20228810 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20228810 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20228810 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20228810 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20228810 | pubmed:issn | 1476-4679 | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:RaposoGraçaG | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:HoflackBernar... | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:KirchhausenTo... | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:SchenckAnnett... | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:BaustThorsten... | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:AniteiMihaela... | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:StangeChristo... | lld:pubmed |
| pubmed-article:20228810 | pubmed:author | pubmed-author:ParshinaIrina... | lld:pubmed |
| pubmed-article:20228810 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20228810 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:20228810 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20228810 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20228810 | pubmed:pagination | 330-40 | lld:pubmed |
| pubmed-article:20228810 | pubmed:dateRevised | 2010-5-5 | lld:pubmed |
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| pubmed-article:20228810 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20228810 | pubmed:articleTitle | Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. | lld:pubmed |
| pubmed-article:20228810 | pubmed:affiliation | Biotechnology Center, Dresden University of Technology, Tatzberg 47-51, 01307 Dresden, Germany. | lld:pubmed |
| pubmed-article:20228810 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20228810 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20228810 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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