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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-3-29
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pubmed:abstractText |
Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride positron emission tomography and blood oxygen level-dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1546-1726
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pubmed:author |
pubmed-author:AnsariM SibMS,
pubmed-author:BaldwinRonald MRM,
pubmed-author:BenningStephen DSD,
pubmed-author:BuckholtzJoshua WJW,
pubmed-author:ColeDavidD,
pubmed-author:CowanRonald LRL,
pubmed-author:KesslerRobert MRM,
pubmed-author:LiRuiR,
pubmed-author:SchwartzmanAshley NAN,
pubmed-author:ShelbyEvan SES,
pubmed-author:SmithClarence ECE,
pubmed-author:TreadwayMichael TMT,
pubmed-author:WoodwardNeil DND,
pubmed-author:ZaldDavid HDH
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-21
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pubmed:dateRevised |
2011-5-3
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pubmed:meshHeading |
pubmed-meshheading:20228805-Adolescent,
pubmed-meshheading:20228805-Adult,
pubmed-meshheading:20228805-Antisocial Personality Disorder,
pubmed-meshheading:20228805-Brain Mapping,
pubmed-meshheading:20228805-Criminals,
pubmed-meshheading:20228805-Dopamine,
pubmed-meshheading:20228805-Female,
pubmed-meshheading:20228805-Humans,
pubmed-meshheading:20228805-Impulsive Behavior,
pubmed-meshheading:20228805-Limbic System,
pubmed-meshheading:20228805-Magnetic Resonance Imaging,
pubmed-meshheading:20228805-Male,
pubmed-meshheading:20228805-Nucleus Accumbens,
pubmed-meshheading:20228805-Personality Assessment,
pubmed-meshheading:20228805-Positron-Emission Tomography,
pubmed-meshheading:20228805-Receptors, Dopamine,
pubmed-meshheading:20228805-Reward,
pubmed-meshheading:20228805-Single-Blind Method,
pubmed-meshheading:20228805-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits.
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pubmed:affiliation |
Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA. joshua.buckholtz@vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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