Linked Life Data

2022721

Source:http://linkedlifedata.com/resource/pubmed/id/2022721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-5-31
pubmed:abstractText
Levels of C-reactive protein (CRP) were evaluated by enzyme immunoassay in patients infected with the filarial parasite Wuchereria bancrofti. Significantly elevated levels of CRP (P less than 0.001) were demonstrated in patients with chronic lymphatic pathology (CP; n = 18) compared to patients with asymptomatic microfilaremia (MF; n = 13) and normal volunteers (NV; n = 29). Serum levels of CRP showed an inverse correlation (rs = -0.37; P less than 0.05) with phosphocholine (PC)-containing filarial antigen that was present in the circulation of patients with bancroftian filariasis. Marked elevations in the percentage of CRP-binding lymphocytes were observed in patients with CP (mean = 44%; P less than 0.001) compared to those with MF (mean = 18%) or NV (mean = 3%). The increased percentage of surface CRP was not due to an abnormal change in major lymphocyte subset (CD5, CD4, CD8, or CD19). No significant correlation was noted between surface CRP and serum CRP; however, an inverse correlation was observed between surface CRP and PC-bearing circulating filarial Ag (rs = -0.64; P less than 0.001). Biosynthetic labeling and immunoprecipitation with anti-CRP antibodies indicated quantitative differences in the synthesis of CRP in patients with CP compared to MF and CP. Complexing of CRP with PC-containing Brugia malayi antigen (CRP-BmA) caused increased binding to normal lymphocytes (less than 8%), but not close to the extent seen in patients with CP (44%), suggesting de novo synthesis of CRP in these patients.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0271-9142
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
46-53
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
C-reactive protein in patients with lymphatic filariasis: increased expression on lymphocytes in chronic lymphatic obstruction.
pubmed:affiliation
Division of Tropical Public Health, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
pubmed:publicationType
Journal Article