| pubmed-article:20226436 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C1521549 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C0042487 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C0034606 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C0016441 | lld:lifeskim |
| pubmed-article:20226436 | lifeskim:mentions | umls-concept:C0441633 | lld:lifeskim |
| pubmed-article:20226436 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20226436 | pubmed:dateCreated | 2010-4-12 | lld:pubmed |
| pubmed-article:20226436 | pubmed:abstractText | To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT. Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT. Indeed, the HIVEP1 rs169713C allele was associated with an increased risk for VT, with an odds ratio of 1.20 (95% confidence interval 1.13-1.27, p = 2.86 x 10(-9)). HIVEP1 codes for a protein that participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions. The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway. | lld:pubmed |
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| pubmed-article:20226436 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20226436 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20226436 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20226436 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20226436 | pubmed:issn | 1537-6605 | lld:pubmed |
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| pubmed-article:20226436 | pubmed:copyrightInfo | (c) 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20226436 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20226436 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:20226436 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:20226436 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20226436 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20226436 | pubmed:pagination | 592-5 | lld:pubmed |
| pubmed-article:20226436 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:20226436 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20226436 | pubmed:articleTitle | A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. | lld:pubmed |
| pubmed-article:20226436 | pubmed:affiliation | INSERM, UMR_S 626, Université de la Méditerranée, Marseille, F-13385 France. pierre.morange@ap-hm.fr | lld:pubmed |
| pubmed-article:20226436 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20226436 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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