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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-12
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pubmed:abstractText |
To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT. Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT. Indeed, the HIVEP1 rs169713C allele was associated with an increased risk for VT, with an odds ratio of 1.20 (95% confidence interval 1.13-1.27, p = 2.86 x 10(-9)). HIVEP1 codes for a protein that participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions. The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-12686699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-12871267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-15701913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-15860560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-16415888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-18673009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-18974171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-19265041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-19278955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-19566544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-19679244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-19912223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-2106471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-2108316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226436-8164730
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1537-6605
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pubmed:author |
pubmed-author:AlessiMarie-ChristineMC,
pubmed-author:BareLanceL,
pubmed-author:BezemerIreneI,
pubmed-author:Biron-AndreaniChristineC,
pubmed-author:BlankenbergStefanS,
pubmed-author:Brand-HerrmannStefan-MartinSM,
pubmed-author:BrochetonJessyJ,
pubmed-author:BurgosGwenaelleG,
pubmed-author:CambienFrançoisF,
pubmed-author:DellucAurélienA,
pubmed-author:DrouetLudovicL,
pubmed-author:DurandHervéH,
pubmed-author:EmmerichJosephJ,
pubmed-author:GalanPilarP,
pubmed-author:GermainMarineM,
pubmed-author:HeathSimonS,
pubmed-author:LathropMarkM,
pubmed-author:MünzelThomasT,
pubmed-author:MorangePierre-EmmanuelPE,
pubmed-author:NicaudVivianeV,
pubmed-author:NinioEwaE,
pubmed-author:PernodGillesG,
pubmed-author:RosendaalFrits RFR,
pubmed-author:SautNoémieN,
pubmed-author:SchvedJean-FrancoisJF,
pubmed-author:TiretLaurenceL,
pubmed-author:TrégouëtDavid-AlexandreDA,
pubmed-author:ZelenikaDianaD,
pubmed-author:ZellerTanjaT
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pubmed:copyrightInfo |
(c) 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
592-5
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20226436-Case-Control Studies,
pubmed-meshheading:20226436-Chromosomes, Human, Pair 6,
pubmed-meshheading:20226436-DNA-Binding Proteins,
pubmed-meshheading:20226436-Follow-Up Studies,
pubmed-meshheading:20226436-Genetic Predisposition to Disease,
pubmed-meshheading:20226436-Genome-Wide Association Study,
pubmed-meshheading:20226436-Humans,
pubmed-meshheading:20226436-Polymorphism, Single Nucleotide,
pubmed-meshheading:20226436-Transcription Factors,
pubmed-meshheading:20226436-Venous Thrombosis
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pubmed:year |
2010
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pubmed:articleTitle |
A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1.
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pubmed:affiliation |
INSERM, UMR_S 626, Université de la Méditerranée, Marseille, F-13385 France. pierre.morange@ap-hm.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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