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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-4-19
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pubmed:abstractText |
The ribonucleotide reductase M1 (RRM1) gene encodes the regulatory subunit of ribonucleotide reductase, the molecular target of gemcitabine. The overexpression of RRM1 mRNA in tumor tissues is reported to be associated with gemcitabine resistance. Thus, single nucleotide polymorphisms (SNPs) of the RRM1 gene are potential biomarkers of the response to gemcitabine chemotherapy. We investigated whether RRM1 expression in peripheral blood mononuclear cells (PBMCs) or SNPs were associated with clinical outcome after gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-10485455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-10716719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-11858971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-12687015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-12789263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-14977831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-15139041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-15140544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-15172981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-15277258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-15603856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-15639717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-16708051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-16966686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-16980606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-17597605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-17602053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-18483375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-19002265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-19474385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-20021861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20226083-7580546
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1756-8722
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20226083-Adenocarcinoma,
pubmed-meshheading:20226083-Adult,
pubmed-meshheading:20226083-Aged,
pubmed-meshheading:20226083-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:20226083-Carboplatin,
pubmed-meshheading:20226083-Carcinoma, Large Cell,
pubmed-meshheading:20226083-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:20226083-Carcinoma, Squamous Cell,
pubmed-meshheading:20226083-Deoxycytidine,
pubmed-meshheading:20226083-Disease-Free Survival,
pubmed-meshheading:20226083-Female,
pubmed-meshheading:20226083-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20226083-Genotype,
pubmed-meshheading:20226083-Humans,
pubmed-meshheading:20226083-Lung Neoplasms,
pubmed-meshheading:20226083-Male,
pubmed-meshheading:20226083-Middle Aged,
pubmed-meshheading:20226083-Polymorphism, Single Nucleotide,
pubmed-meshheading:20226083-Treatment Outcome,
pubmed-meshheading:20226083-Tumor Markers, Biological,
pubmed-meshheading:20226083-Tumor Suppressor Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy.
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pubmed:affiliation |
Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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