20224928

Source:http://linkedlifedata.com/resource/pubmed/id/20224928

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017337, umls-concept:C0020792, umls-concept:C0087111, umls-concept:C0205195, umls-concept:C0215136, umls-concept:C0332281, umls-concept:C0672708, umls-concept:C1512505, umls-concept:C2347610
pubmed:issue	1
pubmed:dateCreated	2010-12-3
pubmed:abstractText	Here we evaluated the cytotoxic effects of a combination of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and taxanes in human breast cancer cell lines. Combination treatment with taxane and SAHA had a synergistic cytotoxic effect against taxane-resistant breast cancer cells. Oligonucleotide microarray analysis identified 28 genes (MAPK13, ATP2C1, ANKRD57, MT1G, RGL4, C12orf49, EXOC6, RAB4A, TM9SF3, IFNGR1, DMD, HCG9, KIFC3, SYNGR3, NDRG4, NT5E, EOMES, SMC4, LANCL1, SCHIP1, and 8 ESTs) whose expression correlated with the combined effect of paclitaxel and SAHA. Twelve of these genes were down-regulated in cell lines that were paclitaxel-resistant but combination synergistic. SAHA induced NT5E mRNA expression in paclitaxel-resistant YCC-B1 cell. Our results indicate that a combination of taxane and SAHA could be efficacious for the treatment of breast cancer and that genes involved in the synergistic response to paclitaxel and SAHA could serve as biomarkers to predict therapeutic response in breast cancer patients.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8111104
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/vorinostat
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	1573-7217
pubmed:author	pubmed-author:ChangHyunH, pubmed-author:ChungHyun CheolHC, pubmed-author:JeungHei-CheulHC, pubmed-author:JungJe JunJJ, pubmed-author:KimTae SooTS, pubmed-author:RhaSun YoungSY
pubmed:issnType	Electronic
pubmed:volume	125
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	55-63
pubmed:meshHeading	pubmed-meshheading:20224928-Antineoplastic Agents, Phytogenic, pubmed-meshheading:20224928-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:20224928-Breast Neoplasms, pubmed-meshheading:20224928-Cell Proliferation, pubmed-meshheading:20224928-Dose-Response Relationship, Drug, pubmed-meshheading:20224928-Drug Resistance, Neoplasm, pubmed-meshheading:20224928-Drug Synergism, pubmed-meshheading:20224928-Female, pubmed-meshheading:20224928-Gene Expression Profiling, pubmed-meshheading:20224928-Gene Expression Regulation, Neoplastic, pubmed-meshheading:20224928-Histone Deacetylase Inhibitors, pubmed-meshheading:20224928-Humans, pubmed-meshheading:20224928-Hydroxamic Acids, pubmed-meshheading:20224928-Inhibitory Concentration 50, pubmed-meshheading:20224928-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:20224928-Paclitaxel, pubmed-meshheading:20224928-RNA, Messenger, pubmed-meshheading:20224928-Reproducibility of Results, pubmed-meshheading:20224928-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year	2011
pubmed:articleTitle	Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells.
pubmed:affiliation	Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't