Linked Life Data

20224871

Source:http://linkedlifedata.com/resource/pubmed/id/20224871

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-6-10
pubmed:abstractText
The short- and long-term effects of pregnancy on breast cancer risk are well documented. Insight into potential biological mechanisms for these associations may be gained by studying breast cancer risk and pregnancy characteristics (e.g., preeclampsia, twining), which may reflect hormone levels during pregnancy. To date, no review has synthesized the published literature for pregnancy characteristics and maternal breast cancer using systematic search methods. We conducted a systematic search to identify all published studies. Using PUBMED (to 31 July 2009), 42 relevant articles were identified. Several studies suggest that multiple births may be associated with a lowered breast cancer risk of about 10-30%, but results were inconsistent across 18 studies. The majority of 13 studies suggest about a 20-30% reduction in risk with preeclampsia and/or gestational hypertension. Six of seven studies reported no association for infant sex and breast cancer risk. Data are sparse and conflicting for other pregnancy characteristics such as gestational age, fetal growth, pregnancy weight gain, gestational diabetes, and placental abnormalities. The most consistent findings in a generally sparse literature are that multiple births and preeclampsia may modestly reduce breast cancer risk. Additional research is needed to elucidate associations between pregnancy characteristics, related hormonal profiles, and breast cancer risk.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1573-7225
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
967-89
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Pregnancy characteristics and maternal breast cancer risk: a review of the epidemiologic literature.
pubmed:affiliation
Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine & Public Health, Vanderbilt University, 2525 West End Avenue, 8th Floor, Nashville, TN 37203-1738, USA. sarah.nechuta@vanderbilt.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural