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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-4-30
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pubmed:abstractText |
Arteriovenous malformations (AVMs) result in anomalous direct blood flow between arteries and veins, bypassing the normal capillary bed. Depending on size and location, AVMs may lead to severe clinical effects including systemic cyanosis (pulmonary AVMs), hemorrhagic stroke (cerebral AVMs) and high output cardiac failure (hepatic AVMs). The factors leading to AVM formation are poorly understood, but patients with the familial disease hereditary hemorrhagic telangiectasia (HHT) develop AVMs at high frequency. As most HHT patients have mutations in ENG (endoglin) or ACVRL1 (activin receptor-like kinase 1), a better understanding of the role of these genes in vascular development is likely to reveal the etiology of AVM formation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4571
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1425-33
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pubmed:meshHeading |
pubmed-meshheading:20224041-Aging,
pubmed-meshheading:20224041-Angiogenic Proteins,
pubmed-meshheading:20224041-Animals,
pubmed-meshheading:20224041-Antigens, CD,
pubmed-meshheading:20224041-Arteriovenous Malformations,
pubmed-meshheading:20224041-Cadherins,
pubmed-meshheading:20224041-Capillaries,
pubmed-meshheading:20224041-Cell Proliferation,
pubmed-meshheading:20224041-Endothelial Cells,
pubmed-meshheading:20224041-Integrases,
pubmed-meshheading:20224041-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20224041-Mice,
pubmed-meshheading:20224041-Mice, Knockout,
pubmed-meshheading:20224041-Mice, Transgenic,
pubmed-meshheading:20224041-Microcirculation,
pubmed-meshheading:20224041-Mutation,
pubmed-meshheading:20224041-Neovascularization, Pathologic,
pubmed-meshheading:20224041-Regional Blood Flow,
pubmed-meshheading:20224041-Retinal Neovascularization
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pubmed:year |
2010
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pubmed:articleTitle |
Pathogenesis of arteriovenous malformations in the absence of endoglin.
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pubmed:affiliation |
Institute of Human Genetics, Centre for Life, Newcastle University, NE1 3BZ, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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