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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1991-5-31
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M31698,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M31699,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M36682,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M57947,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M57949,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M57950,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M58399,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M58400,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M58401,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M58402
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pubmed:abstractText |
A galactoside-binding lectin (Mr 29,000) has previously been identified in rat, mouse and human tissues. It is an abundant cell-surface component of inflammatory macrophages and their major non-integrin laminin-binding protein. It has also been found in the nucleus of other cell types. Here, we report the cloning and sequencing of a cDNA encoding the human galactoside-binding lectin from a breast carcinoma. The clone encodes a protein of 250 amino acids (aa) that is over 80% identical to its mouse and rat counterparts. The aa sequence has an N-terminal and a C-terminal, 'carbohydrate-binding', domain. The N-terminal domain consists of two parts. The first 41 aa are homologous to a transcription factor, i.e., the serum response factor. The adjacent part (aa 42-106) contains an unusual repeating element, that occurs seven times in human protein compared to nine times in rat and mouse. The C-terminal 'carbohydrate-binding' domain (aa 115-250) shows homology to L-14, another galactoside-binding lectin.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0378-1119
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
99
|
pubmed:geneSymbol |
Mac-2,
l-29
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
279-83
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2022338-Amino Acid Sequence,
pubmed-meshheading:2022338-Base Sequence,
pubmed-meshheading:2022338-Breast Neoplasms,
pubmed-meshheading:2022338-Carrier Proteins,
pubmed-meshheading:2022338-Galectins,
pubmed-meshheading:2022338-Hemagglutinins,
pubmed-meshheading:2022338-Humans,
pubmed-meshheading:2022338-Molecular Sequence Data,
pubmed-meshheading:2022338-Multigene Family,
pubmed-meshheading:2022338-Sequence Homology, Nucleic Acid
|
pubmed:year |
1991
|
pubmed:articleTitle |
Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen.
|
pubmed:affiliation |
Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco 94143-0984.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|