Linked Life Data

20220571

Source:http://linkedlifedata.com/resource/pubmed/id/20220571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-5-4
pubmed:abstractText
BACKGROUND.: Adhesion molecules play a key role in the recruitment of leukocytes to sites of inflammation. Genetic polymorphisms of adhesion molecules may alter their expression or function and may thereby influence the process of leukocyte infiltration in the transplanted organ. It has also been suggested that polymorphic adhesion molecules may act as minor histocompatibility antigens. METHODS.: In two randomly selected cohorts (954 and 1002 kidney transplants), the effect of L-selectin/CD62L (codon 206 and 213), platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31; codon 125, 563, and 670), and activated leukocyte cell adhesion molecule (ALCAM/CD166; codon 258) single nucleotide polymorphisms on 5-yr allograft survival was investigated. DNA samples and clinical data were provided by the Collaborative Transplant Study. Recipients and donors were genotyped by polymerase chain reaction sequence-specific primer. A multivariate analysis was performed using a Cox regression model. RESULTS.: Incompatibility for L-selectin at codon 213 was significantly associated with better graft survival in the first cohort, but the effect could not be replicated in the second cohort. Polymorphisms of PECAM-1 and ALCAM had no impact on graft outcome. CONCLUSIONS.: This is the first comprehensive and large-scale study on the relevance of L-selectin, PECAM-1, and ALCAM genetic polymorphisms in kidney transplantation, showing no significant associations of recipient or donor genotypes with allograft survival. Because the effect of L-selectin mismatch was not reproducible, a putative role of adhesion molecules as minor histocompatibility antigens cannot be confirmed. Our results demonstrate the importance of testing large sample sizes and of performing confirmation studies to validate genetic associations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1534-6080
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1079-87
pubmed:meshHeading
pubmed-meshheading:20220571-Activated-Leukocyte Cell Adhesion Molecule, pubmed-meshheading:20220571-Adult, pubmed-meshheading:20220571-Antigens, CD31, pubmed-meshheading:20220571-Cadaver, pubmed-meshheading:20220571-Codon, pubmed-meshheading:20220571-DNA Primers, pubmed-meshheading:20220571-Databases, Nucleic Acid, pubmed-meshheading:20220571-European Continental Ancestry Group, pubmed-meshheading:20220571-Female, pubmed-meshheading:20220571-Graft Survival, pubmed-meshheading:20220571-HLA-A Antigens, pubmed-meshheading:20220571-HLA-B Antigens, pubmed-meshheading:20220571-HLA-DR Antigens, pubmed-meshheading:20220571-Humans, pubmed-meshheading:20220571-Kidney Transplantation, pubmed-meshheading:20220571-L-Selectin, pubmed-meshheading:20220571-Male, pubmed-meshheading:20220571-Middle Aged, pubmed-meshheading:20220571-Patient Selection, pubmed-meshheading:20220571-Polymerase Chain Reaction, pubmed-meshheading:20220571-Polymorphism, Genetic, pubmed-meshheading:20220571-Tissue Donors, pubmed-meshheading:20220571-Transplantation, Homologous
pubmed:year
2010
pubmed:articleTitle
Genetic polymorphisms of adhesion molecules and kidney transplant survival.
pubmed:affiliation
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't