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pubmed-article:20219694pubmed:abstractTextLung development depends on accurate and precise patterning of a pulmonary anlagen, consisting of both endodermally and mesodermally derived progenitor cells. In this process, the need to establish communication and control among individual cells is paramount. Transforming growth factor-beta (TGFbeta) and Wingless/int (Wnt) signaling pathways serve this need. The individual functional repertoire of the two pathways is further expanded by cross-talk and integration of signaling at multiple levels taking advantage of their hard-wired multi-component signal transduction platforms. Cross-talk creates the possibility for both specificity and versatility in signaling during development and during repair of injured tissue. Understanding the mechanics and the physiological implications of this cross-talk is necessary for therapeutic or preventive targeting of either TGFbeta or Wnt signaling pathways.lld:pubmed
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pubmed-article:20219694pubmed:authorpubmed-author:LiChanggongClld:pubmed
pubmed-article:20219694pubmed:authorpubmed-author:MinooParvizPlld:pubmed
pubmed-article:20219694pubmed:copyrightInfoCopyright 2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:20219694pubmed:articleTitleCross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease.lld:pubmed
pubmed-article:20219694pubmed:affiliationDivision of Neonatology, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. minoo@usc.edulld:pubmed
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