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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-3
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pubmed:abstractText |
Lung development depends on accurate and precise patterning of a pulmonary anlagen, consisting of both endodermally and mesodermally derived progenitor cells. In this process, the need to establish communication and control among individual cells is paramount. Transforming growth factor-beta (TGFbeta) and Wingless/int (Wnt) signaling pathways serve this need. The individual functional repertoire of the two pathways is further expanded by cross-talk and integration of signaling at multiple levels taking advantage of their hard-wired multi-component signal transduction platforms. Cross-talk creates the possibility for both specificity and versatility in signaling during development and during repair of injured tissue. Understanding the mechanics and the physiological implications of this cross-talk is necessary for therapeutic or preventive targeting of either TGFbeta or Wnt signaling pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20219694-10828572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20219694-10890911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20219694-11688567,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20219694-9507084
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1878-5875
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
809-12
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20219694-Animals,
pubmed-meshheading:20219694-Cell Communication,
pubmed-meshheading:20219694-Humans,
pubmed-meshheading:20219694-Lung,
pubmed-meshheading:20219694-Organogenesis,
pubmed-meshheading:20219694-Receptor Cross-Talk,
pubmed-meshheading:20219694-Regeneration,
pubmed-meshheading:20219694-Respiratory Mucosa,
pubmed-meshheading:20219694-Signal Transduction,
pubmed-meshheading:20219694-Transforming Growth Factor beta,
pubmed-meshheading:20219694-Wnt Proteins,
pubmed-meshheading:20219694-Wound Healing
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pubmed:year |
2010
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pubmed:articleTitle |
Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease.
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pubmed:affiliation |
Division of Neonatology, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. minoo@usc.edu
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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