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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2010-3-22
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pubmed:abstractText |
In the course of search for the robust analogs of 1'-acetoxychavicol acetate (ACA, 1), the Rev-export inhibitor from the medicinal plant Alpinia galanga, we clarified formation of the quinone methide intermediate ii to be essential for exerting the inhibitory activity of 1. Based on this mechanism of action, the rational design from the MO calculation of the conclusive activation energy to ii resulted in the four halogenated analogs with more potent activity than ACA (1). In particular, the difluoroanalog 20d exhibited approximately four-fold potent activity as compared with 1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2082-5
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pubmed:meshHeading |
pubmed-meshheading:20219373-Alpinia,
pubmed-meshheading:20219373-Animals,
pubmed-meshheading:20219373-Anti-HIV Agents,
pubmed-meshheading:20219373-Benzyl Alcohols,
pubmed-meshheading:20219373-Cattle,
pubmed-meshheading:20219373-Genes, rev,
pubmed-meshheading:20219373-HIV Infections,
pubmed-meshheading:20219373-HIV-1,
pubmed-meshheading:20219373-HeLa Cells,
pubmed-meshheading:20219373-Humans,
pubmed-meshheading:20219373-Hydrocarbons, Halogenated,
pubmed-meshheading:20219373-Plant Extracts
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pubmed:year |
2010
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pubmed:articleTitle |
Halogenated analogs of 1'-acetoxychavicol acetate, Rev-export inhibitor from Alpinia galanga, designed from mechanism of action.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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