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rdf:type |
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lifeskim:mentions |
umls-concept:C0011615,
umls-concept:C0017337,
umls-concept:C0017968,
umls-concept:C0027740,
umls-concept:C0162809,
umls-concept:C0178587,
umls-concept:C0221920,
umls-concept:C0241764,
umls-concept:C0521119,
umls-concept:C1314939,
umls-concept:C1416536,
umls-concept:C1709059,
umls-concept:C2700447,
umls-concept:C2700640
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pubmed:issue |
1
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pubmed:dateCreated |
2010-3-16
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|
pubmed:abstractText |
Epidermal nerve density is increased in atopic dermatitis (AD), suggesting that the hyperinnervation is partly responsible for abnormal itch perception. It is probably controlled by axonal guidance molecules produced by keratinocytes. An extracellular matrix glycoprotein anosmin-1 encoded by KAL1 has chemoattractive or chemorepulsive effects on different neuronal types.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-569X
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
64-71
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pubmed:meshHeading |
pubmed-meshheading:20219326-Adult,
pubmed-meshheading:20219326-Animals,
pubmed-meshheading:20219326-Biopsy,
pubmed-meshheading:20219326-Cell Differentiation,
pubmed-meshheading:20219326-Cells, Cultured,
pubmed-meshheading:20219326-Dermatitis, Atopic,
pubmed-meshheading:20219326-Down-Regulation,
pubmed-meshheading:20219326-Epidermis,
pubmed-meshheading:20219326-Extracellular Matrix Proteins,
pubmed-meshheading:20219326-Female,
pubmed-meshheading:20219326-Humans,
pubmed-meshheading:20219326-Interleukin-13,
pubmed-meshheading:20219326-Interleukin-4,
pubmed-meshheading:20219326-Keratinocytes,
pubmed-meshheading:20219326-Male,
pubmed-meshheading:20219326-Mice,
pubmed-meshheading:20219326-Mice, Inbred ICR,
pubmed-meshheading:20219326-Nerve Tissue Proteins,
pubmed-meshheading:20219326-Neurons,
pubmed-meshheading:20219326-Rats,
pubmed-meshheading:20219326-Transforming Growth Factor beta1
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pubmed:year |
2010
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pubmed:articleTitle |
Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis.
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pubmed:affiliation |
Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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