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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0084024,
umls-concept:C0162768,
umls-concept:C0851285,
umls-concept:C1324593,
umls-concept:C1511938,
umls-concept:C1514562,
umls-concept:C1705998,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
8
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pubmed:dateCreated |
2010-6-11
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|
pubmed:abstractText |
Acute myeloid leukemia (AML) is frequently associated with chromosomal translocations. These translocations produce specific fusion genes that play crucial roles in leukemogenesis. We recently identified a novel NUP98-PHF23 fusion in AML. In this study, we attempt to determine the role of NUP98-PHF23 protein and its plant homeodomain (PHD) and coiled-coil domain in regulation of cellular differentiation and protein distribution. We provide evidence that NUP98-PHF23, through its PHD domain, impairs TPA-induced differentiation of K562 cells. While the fusion protein localizes to the nucleus, its deletion mutant without the PHD domain resides exclusively in the nucleolus, suggesting a potential link between chromatin-binding PHD domain and nuclear architecture.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1873-5835
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1094-7
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pubmed:meshHeading |
pubmed-meshheading:20219246-Animals,
pubmed-meshheading:20219246-Blotting, Western,
pubmed-meshheading:20219246-Cell Differentiation,
pubmed-meshheading:20219246-Cell Nucleus,
pubmed-meshheading:20219246-Flow Cytometry,
pubmed-meshheading:20219246-Homeodomain Proteins,
pubmed-meshheading:20219246-Humans,
pubmed-meshheading:20219246-K562 Cells,
pubmed-meshheading:20219246-Leukemia, Myeloid, Acute,
pubmed-meshheading:20219246-Mice,
pubmed-meshheading:20219246-NIH 3T3 Cells,
pubmed-meshheading:20219246-Nuclear Pore Complex Proteins,
pubmed-meshheading:20219246-Oncogene Proteins, Fusion,
pubmed-meshheading:20219246-Protein Structure, Tertiary,
pubmed-meshheading:20219246-Pyridines,
pubmed-meshheading:20219246-Sequence Deletion,
pubmed-meshheading:20219246-Translocation, Genetic
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pubmed:year |
2010
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pubmed:articleTitle |
Regulation of differentiation by a PHD domain in the NUP98-PHF23 fusion protein.
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pubmed:affiliation |
Department of Pathology, University of Maryland, School of Medicine, 10 S. Pine St., MSTF-717, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article
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