Linked Life Data

20218960

Source:http://linkedlifedata.com/resource/pubmed/id/20218960

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-3-11
pubmed:abstractText
Chemokines, a group of proinflammatory chemotactic cytokines, function to recruit leukocytes to inflammation sites, but they also play important roles in tumor growth, angiogenesis, organ sclerosis, and autoimmunity. In recent years, increasing evidence has accumulated to support the concept that thyroid epithelial cells (TEC) as well as the lymphocytes infiltrating into the thyroid are capable of producing CC and CXC chemokines. They, in turn, promote the initiation and maintenance of an inflammatory response, resulting in the development of autoimmune thyroiditis. This review focused on the role of chemokines in the pathogenesis in the two well-defined murine models of autoimmune thyroiditis, experimentally autoimmune thyroiditis (EAT) in DBA/1 and CBA/J mice and iodine-induced spontaneous autoimmune thyroiditis (SAT) in NOD.H-2h4 mice. Recent patents which focus on chemokines as novel therapeutic targets in autoimmune thyroiditis were also discussed in this review. Such study might improve our knowledge about the roles of chemokines in autoimmune thyroiditis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
2212-3431
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-7
pubmed:dateRevised
2011-11-10
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Chemokines as novel therapeutic targets in autoimmune thyroiditis.
pubmed:affiliation
Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA. fangy@health.missouri.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural