| pubmed-article:20217550 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20217550 | lifeskim:mentions | umls-concept:C0007987 | lld:lifeskim |
| pubmed-article:20217550 | lifeskim:mentions | umls-concept:C1099354 | lld:lifeskim |
| pubmed-article:20217550 | pubmed:dateCreated | 2010-3-10 | lld:pubmed |
| pubmed-article:20217550 | pubmed:abstractText | Chemical synthesis has been a major endeavor to create active siRNAs. The downregulation of mRNA by 21-mer double-stranded siRNAs can be improved by using modified nucleotides, especially 2'-O-alkylated ones. Besides the commercially available 2 cent-O-methyl ribosides, 2'-alkyl groups bearing positive charges are especially promising candidates. We have shown that in a proper formulation they are superior to unmodified siRNAs. This may be due to enhanced stability and most probably to a better uptake into the cells. | lld:pubmed |
| pubmed-article:20217550 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20217550 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20217550 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20217550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20217550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20217550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20217550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20217550 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20217550 | pubmed:issn | 1940-6029 | lld:pubmed |
| pubmed-article:20217550 | pubmed:author | pubmed-author:EngelsJoachim... | lld:pubmed |
| pubmed-article:20217550 | pubmed:author | pubmed-author:HaasJensJ | lld:pubmed |
| pubmed-article:20217550 | pubmed:author | pubmed-author:SmiciusRomual... | lld:pubmed |
| pubmed-article:20217550 | pubmed:author | pubmed-author:OdadzicDalibo... | lld:pubmed |
| pubmed-article:20217550 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20217550 | pubmed:volume | 623 | lld:pubmed |
| pubmed-article:20217550 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20217550 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20217550 | pubmed:pagination | 155-70 | lld:pubmed |
| pubmed-article:20217550 | pubmed:meshHeading | pubmed-meshheading:20217550... | lld:pubmed |
| pubmed-article:20217550 | pubmed:meshHeading | pubmed-meshheading:20217550... | lld:pubmed |
| pubmed-article:20217550 | pubmed:meshHeading | pubmed-meshheading:20217550... | lld:pubmed |
| pubmed-article:20217550 | pubmed:meshHeading | pubmed-meshheading:20217550... | lld:pubmed |
| pubmed-article:20217550 | pubmed:meshHeading | pubmed-meshheading:20217550... | lld:pubmed |
| pubmed-article:20217550 | pubmed:meshHeading | pubmed-meshheading:20217550... | lld:pubmed |
| pubmed-article:20217550 | pubmed:meshHeading | pubmed-meshheading:20217550... | lld:pubmed |
| pubmed-article:20217550 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20217550 | pubmed:articleTitle | Chemical synthesis of 2'-O-alkylated siRNAs. | lld:pubmed |
| pubmed-article:20217550 | pubmed:affiliation | Institute of Organic Chemistry and Chemical Biology, J.W. Goethe-Universität, Frankfurt am Main, Germany. | lld:pubmed |
| pubmed-article:20217550 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20217550 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
