Source:http://linkedlifedata.com/resource/pubmed/id/20217550
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-3-10
|
| pubmed:abstractText |
Chemical synthesis has been a major endeavor to create active siRNAs. The downregulation of mRNA by 21-mer double-stranded siRNAs can be improved by using modified nucleotides, especially 2'-O-alkylated ones. Besides the commercially available 2 cent-O-methyl ribosides, 2'-alkyl groups bearing positive charges are especially promising candidates. We have shown that in a proper formulation they are superior to unmodified siRNAs. This may be due to enhanced stability and most probably to a better uptake into the cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1940-6029
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
623
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
155-70
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| pubmed:meshHeading |
pubmed-meshheading:20217550-Alkylation,
pubmed-meshheading:20217550-Chromatography, High Pressure Liquid,
pubmed-meshheading:20217550-Down-Regulation,
pubmed-meshheading:20217550-Mass Spectrometry,
pubmed-meshheading:20217550-Organophosphorus Compounds,
pubmed-meshheading:20217550-RNA, Messenger,
pubmed-meshheading:20217550-RNA, Small Interfering
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Chemical synthesis of 2'-O-alkylated siRNAs.
|
| pubmed:affiliation |
Institute of Organic Chemistry and Chemical Biology, J.W. Goethe-Universität, Frankfurt am Main, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|