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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-3-19
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pubmed:abstractText |
The antitumor mechanism of histone deacetylase (HDAC) inhibitors differs from conventional antitumor agents. HDAC inhibitors may be effective as novel therapeutic agents for esophageal squamous cell carcinoma (ESCC). This study describes the antiproliferative activity of CHAP31, a novel HDAC inhibitor. Furthermore, the molecular mechanism of CHAP31-induced apoptosis was investigated in ESCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0232
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pubmed:author |
pubmed-author:AkutsuYasunoriY,
pubmed-author:HisahiroMatsubaraM,
pubmed-author:HoshinoIsamuI,
pubmed-author:KanoMasayukiM,
pubmed-author:MatsushitaKazuyukiK,
pubmed-author:MiyazawaYukimasaY,
pubmed-author:MurakamiKentaroK,
pubmed-author:NishimoriTakanoriT,
pubmed-author:NishinoNorikazuN,
pubmed-author:SakataHaruhitoH,
pubmed-author:UsuiAkihiroA,
pubmed-author:YoshidaMinoruM
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pubmed:copyrightInfo |
Copyright 2010 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
62-74
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pubmed:meshHeading |
pubmed-meshheading:20215787-Apoptosis,
pubmed-meshheading:20215787-Carcinoma, Squamous Cell,
pubmed-meshheading:20215787-Cell Line, Tumor,
pubmed-meshheading:20215787-Cell Proliferation,
pubmed-meshheading:20215787-Esophageal Neoplasms,
pubmed-meshheading:20215787-Histone Deacetylase Inhibitors,
pubmed-meshheading:20215787-Humans,
pubmed-meshheading:20215787-Peptides, Cyclic
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pubmed:year |
2010
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pubmed:articleTitle |
CHAP31 induces apoptosis only via the intrinsic pathway in human esophageal cancer cells.
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pubmed:affiliation |
Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. matsuhm @ faculty.chiba-u.jp
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pubmed:publicationType |
Journal Article
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