9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) is one of the most active antiproliferative compounds in a series of acyclic nucleoside phosphonates and is active in intraperitoneal P388 tumors in mice.
Department of Medicine, University of California, San Diego, La Jolla, Calif., and Veterans Medical Research Foundation, San Diego, CA 92093-0676, USA.