Source:http://linkedlifedata.com/resource/pubmed/id/20213817
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2010-4-28
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| pubmed:abstractText |
We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off- and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1531-8257
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| pubmed:author |
pubmed-author:AgidYvesY,
pubmed-author:AlbaneseAlbertoA,
pubmed-author:BenabidAlim LAL,
pubmed-author:BentivoglioAnna RAR,
pubmed-author:ContarinoMaria FMF,
pubmed-author:CornuPhilippeP,
pubmed-author:DormontDidierD,
pubmed-author:EkbergRonR,
pubmed-author:FraixValerieV,
pubmed-author:GironellAndresA,
pubmed-author:GuridiJorgeJ,
pubmed-author:HarizMarwan IMI,
pubmed-author:HouetoJean-LucJL,
pubmed-author:JanssensMarcM,
pubmed-author:KulisevskyJaimeJ,
pubmed-author:LangAnthony EAE,
pubmed-author:LozanoAndres MAM,
pubmed-author:MendesAlexandreA,
pubmed-author:MoroElenaE,
pubmed-author:ObesoJose AJA,
pubmed-author:PollakPierreP,
pubmed-author:QuinnNiall PNP,
pubmed-author:RehncronaStigS,
pubmed-author:Rodriguez-OrozMaria CMC,
pubmed-author:RomitoLuigiL,
pubmed-author:ScerratiMassimoM,
pubmed-author:SchnitzlerAlfonsA,
pubmed-author:SpeelmanJans DJD,
pubmed-author:TimmermannLarsL,
pubmed-author:TornqvistAnnalena LAL,
pubmed-author:VolkmannJensJ,
pubmed-author:WelterMarie-LaureML,
pubmed-author:WojteckiLarsL
|
| pubmed:copyrightInfo |
(c) 2010 Movement Disorder Society.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
578-86
|
| pubmed:meshHeading |
pubmed-meshheading:20213817-Aged,
pubmed-meshheading:20213817-Cross-Over Studies,
pubmed-meshheading:20213817-Deep Brain Stimulation,
pubmed-meshheading:20213817-Double-Blind Method,
pubmed-meshheading:20213817-Female,
pubmed-meshheading:20213817-Follow-Up Studies,
pubmed-meshheading:20213817-Globus Pallidus,
pubmed-meshheading:20213817-Humans,
pubmed-meshheading:20213817-Male,
pubmed-meshheading:20213817-Middle Aged,
pubmed-meshheading:20213817-Parkinson Disease,
pubmed-meshheading:20213817-Severity of Illness Index,
pubmed-meshheading:20213817-Subthalamus,
pubmed-meshheading:20213817-Time Factors,
pubmed-meshheading:20213817-Treatment Outcome
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease.
|
| pubmed:affiliation |
Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network, Toronto, Ontario, Canada. elena.moro@uhn.on.ca
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study
|