| pubmed-article:20213584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C0030281 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C0072980 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C0167117 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C1366876 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C1833235 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:20213584 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:20213584 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20213584 | pubmed:dateCreated | 2010-5-4 | lld:pubmed |
| pubmed-article:20213584 | pubmed:abstractText | It has been reported that the immunosuppressant rapamycin decreases the viability of pancreatic beta cells. In contrast, exendin-4, an analogue of glucagon-like peptide-1, has been found to inhibit beta cell death and to increase beta cell mass. We investigated the effects of exendin-4 on the cytotoxic effect of rapamycin in beta cells. Incubation with 10 nM rapamycin induced cell death in 12 h in murine beta cell line MIN6 cells and Wistar rat islets, but not when coincubated with 10 nM exendin-4. Rapamycin was found to increase phosphorylation of c-Jun amino-terminal kinase (JNK) and p38 in 30 minutes in MIN6 cells and Wistar rat islets while exendin-4 decreased their phosphorylation. Akt and extracellular signal-regulated kinase (ERK) were not involved in the cytoprotective effect of exendin-4. These results indicate that exendin-4 may exert its protective effect against rapamycin-induced cell death in pancreatic beta cells by inhibiting JNK and p38 signaling. | lld:pubmed |
| pubmed-article:20213584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20213584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20213584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20213584 | pubmed:month | May | lld:pubmed |
| pubmed-article:20213584 | pubmed:issn | 1439-4286 | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:YamadaYY | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:SasakiMM | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:NakamuraYY | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:ToyodaKK | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:SeinoYY | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:HarashimaSS | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:HaradaNN | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:YamaneSS | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:YamadaCC | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:HamasakiAA | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:MukaiEE | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:KawasakiYY | lld:pubmed |
| pubmed-article:20213584 | pubmed:author | pubmed-author:InagakiNN | lld:pubmed |
| pubmed-article:20213584 | pubmed:copyrightInfo | Georg Thieme Verlag KG Stuttgart-New York. | lld:pubmed |
| pubmed-article:20213584 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20213584 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:20213584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20213584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20213584 | pubmed:pagination | 311-7 | lld:pubmed |
| pubmed-article:20213584 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20213584 | pubmed:meshHeading | pubmed-meshheading:20213584... | lld:pubmed |
| pubmed-article:20213584 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20213584 | pubmed:articleTitle | Exendin-4 protects pancreatic beta cells from the cytotoxic effect of rapamycin by inhibiting JNK and p38 phosphorylation. | lld:pubmed |
| pubmed-article:20213584 | pubmed:affiliation | Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan. | lld:pubmed |
| pubmed-article:20213584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20213584 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
