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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-3-9
pubmed:abstractText
Hematogenous spread of tumor cells is an early event in osteosarcoma and present in the majority of patients at primary diagnosis. Eradication of such micrometastases by adjuvant combination chemotherapy is crucial for survival. However, a survival plateau of 60-70% was reached over two decades ago, above which it seems difficult to further advance with the currently available therapies. In this study we have, by an immunomagnetic isolation procedure, examined the presence and prognostic impact of disseminated tumor cells in bone marrow aspirates taken at primary diagnosis in a cohort of 41 non-metastatic patients with extremity localized, high-grade osteosarcoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0927-3042
pubmed:author
pubmed:issnType
Print
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
509-15
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic osteosarcoma patients.
pubmed:affiliation
Faculty of Medicine, University of Oslo and Department of Oncology, The Norwegian Radium Hospital, N-0310, Oslo, Norway. oyvind.bruland@medisin.uio.no
pubmed:publicationType
Journal Article