Source:http://linkedlifedata.com/resource/pubmed/id/20212270
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-3-18
|
| pubmed:abstractText |
In previous studies, of which several were underpowered, the relation between cardiovascular outcome and blood pressure (BP) variability was inconsistent. We followed health outcomes in 8938 subjects (mean age: 53.0 years; 46.8% women) randomly recruited from 11 populations. At baseline, we assessed BP variability from the SD and average real variability in 24-hour ambulatory BP recordings. We computed standardized hazard ratios (HRs) while stratifying by cohort and adjusting for 24-hour BP and other risk factors. Over 11.3 years (median), 1242 deaths (487 cardiovascular) occurred, and 1049, 577, 421, and 457 participants experienced a fatal or nonfatal cardiovascular, cardiac, or coronary event or a stroke. Higher diastolic average real variability in 24-hour ambulatory BP recordings predicted (P<or=0.03) total (HR: 1.14) and cardiovascular (HR: 1.21) mortality and all types of fatal combined with nonfatal end points (HR: >or=1.07) with the exception of cardiac and coronary events (HR: <or=1.02; P>or=0.58). Higher systolic average real variability in 24-hour ambulatory BP recordings predicted (P<0.05) total (HR: 1.11) and cardiovascular (HR: 1.16) mortality and all fatal combined with nonfatal end points (HR: >or=1.07), with the exception of cardiac and coronary events (HR: <or=1.03; P>or=0.54). SD predicted only total and cardiovascular mortality. While accounting for the 24-hour BP level, average real variability in 24-hour ambulatory BP recordings added <1% to the prediction of a cardiovascular event. Sensitivity analyses considering ethnicity, sex, age, previous cardiovascular disease, antihypertensive treatment, number of BP readings per recording, or the night:day BP ratio were confirmatory. In conclusion, in a large population cohort, which provided sufficient statistical power, BP variability assessed from 24-hour ambulatory recordings did not contribute much to risk stratification over and beyond 24-hour BP.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1524-4563
|
| pubmed:author |
pubmed-author:Björklund-BodegårdKristinaK,
pubmed-author:BoggiaJoséJ,
pubmed-author:CasigliaEdoardoE,
pubmed-author:DolanEamonE,
pubmed-author:FanP FPF,
pubmed-author:HansenTine WTW,
pubmed-author:IbsenHansH,
pubmed-author:ImaiYutakaY,
pubmed-author:International Database on Ambulatory Blood Pressure in Relation to...,
pubmed-author:JeppesenJørgenJ,
pubmed-author:Kawecka-JaszczKalinaK,
pubmed-author:KikuyaMasahiroM,
pubmed-author:KuznetsovaTatianaT,
pubmed-author:LiYanY,
pubmed-author:MalyutinaSofiaS,
pubmed-author:NikitinYuriY,
pubmed-author:O'BrienEoinE,
pubmed-author:OhkuboTakayoshiT,
pubmed-author:RichartTomT,
pubmed-author:SandoyaEdgardoE,
pubmed-author:StaessenJan AJA,
pubmed-author:Stolarz-SkrzypekKatarzynaK,
pubmed-author:ThijsLutgardeL,
pubmed-author:TikhonoffValérieV,
pubmed-author:Torp-PedersenChristianC,
pubmed-author:WangJiguangJ
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1049-57
|
| pubmed:dateRevised |
2010-7-20
|
| pubmed:meshHeading |
pubmed-meshheading:20212270-Blood Pressure,
pubmed-meshheading:20212270-Blood Pressure Monitoring, Ambulatory,
pubmed-meshheading:20212270-Cardiovascular Diseases,
pubmed-meshheading:20212270-Circadian Rhythm,
pubmed-meshheading:20212270-Databases, Factual,
pubmed-meshheading:20212270-Female,
pubmed-meshheading:20212270-Humans,
pubmed-meshheading:20212270-Incidence,
pubmed-meshheading:20212270-Male,
pubmed-meshheading:20212270-Middle Aged,
pubmed-meshheading:20212270-Prognosis,
pubmed-meshheading:20212270-Proportional Hazards Models,
pubmed-meshheading:20212270-Questionnaires,
pubmed-meshheading:20212270-Risk Factors
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations.
|
| pubmed:affiliation |
Department of Clinical Physiology, Faculty of Health Sciences, Hvidovre University Hospital, Research Center for Prevention and Health, Copenhagen, Denmark.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|