Linked Life Data

20211041

Source:http://linkedlifedata.com/resource/pubmed/id/20211041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-6-16
pubmed:abstractText
The slow digestible disaccharide isomaltulose (iso; Palatinose) is available as novel functional carbohydrate ingredient for manufacturing of low glycaemic foods and beverages. Although basically characterised, various information on physiological effects of iso are still lacking. Thus, the objective of the present study was to expand scientific knowledge of physiological characteristics of iso by a set of three human intervention trials. Using an ileostomy model, iso was found to be essentially absorbed, irrespective of the nature of food (beverage and solid food). Apparent digestibility of 50 g iso from two different meals was 95.5 and 98.8 %; apparent absorption was 93.6 and 96.1 %, respectively. In healthy volunteers, a single dose intake of iso resulted in lower postprandial blood glucose and insulin responses than did sucrose (suc), while showing prolonged blood glucose delivery over 3 h test. In a 4-week trial with hyperlipidaemic individuals, regular consumption of 50 g/d iso within a Western-type diet was well tolerated and did not affect blood lipids. Fasting blood glucose and insulin resistance were lower after the 4-week iso intervention compared with baseline. This would be consistent with possible beneficial metabolic effects as a consequence of the lower and prolonged glycaemic response and lower insulinaemic burden. However, there was no significant difference at 4 weeks after iso compared with suc. In conclusion, the study shows that iso is completely available from the small intestine, irrespective of food matrix, leading to a prolonged delivery of blood glucose. Regular iso consumption is well tolerated also in subjects with increased risk for vascular diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1475-2662
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1730-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20211041-Adult, pubmed-meshheading:20211041-Aged, pubmed-meshheading:20211041-Blood Glucose, pubmed-meshheading:20211041-Cross-Over Studies, pubmed-meshheading:20211041-Dietary Carbohydrates, pubmed-meshheading:20211041-Digestion, pubmed-meshheading:20211041-Double-Blind Method, pubmed-meshheading:20211041-Female, pubmed-meshheading:20211041-Functional Food, pubmed-meshheading:20211041-Glycemic Index, pubmed-meshheading:20211041-Humans, pubmed-meshheading:20211041-Hyperlipidemias, pubmed-meshheading:20211041-Ileostomy, pubmed-meshheading:20211041-Insulin, pubmed-meshheading:20211041-Insulin Resistance, pubmed-meshheading:20211041-Intestinal Absorption, pubmed-meshheading:20211041-Isomaltose, pubmed-meshheading:20211041-Lipids, pubmed-meshheading:20211041-Male, pubmed-meshheading:20211041-Middle Aged, pubmed-meshheading:20211041-Postprandial Period, pubmed-meshheading:20211041-Reference Values, pubmed-meshheading:20211041-Sucrose, pubmed-meshheading:20211041-Young Adult
pubmed:year
2010
pubmed:articleTitle
Novel findings on the metabolic effects of the low glycaemic carbohydrate isomaltulose (Palatinose).
pubmed:affiliation
Department of Medicine II, Division of Gastroenterology, University of Würzburg, Würzburg, Germany. holub_i@medizin.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't