Linked Life Data

20209877

Source:http://linkedlifedata.com/resource/pubmed/id/20209877

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-3-8
pubmed:abstractText
Studies on the neurobiological background of anxiety indicate that the patogenesis of anxiety may be related to the process of an extinction of aversive memories. It has been suggested that disruption of selective attention for emotional stimuli may confer the risk for mental disorders, such as phobias and post-traumatic stress disorder, PTSD. Differences in the effects of local neuronal and hormonal activities of the HPA axis on emotional memory formation, might underlie individual differences in the emotional reactivity. Studies on molecular and cellular mechanisms responsible for individual fear extinction may serve as the basis of search for more effective forms of clinical treatment of anxiety. Behavioural therapy of phobias and PTSD can be facilitated by D-cycloserine (the agonist at the glycine site of the NMDA receptor), ligands stimulating endogenous cannabinoid system and by gluocorticosteroids. Although all these substances stimulate different central mechanisms, they appear to act synergistically, to improve the behavioural therapy.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0033-2674
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
639-53
pubmed:meshHeading
pubmed:articleTitle
[Extinction of emotional response as a novel approach of pharmacotherapy of anxiety disorders].
pubmed:affiliation
Zak?ad Neurochemii IPiN w Warszawie.
pubmed:publicationType
Journal Article, English Abstract, Review