Source:http://linkedlifedata.com/resource/pubmed/id/20209637
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-3-15
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| pubmed:abstractText |
Acute graft-versus-host disease (aGVHD) is a serious complication of liver transplantation (LTx); it occurs in 1% to 2% of liver allograft recipients. The condition has a poor prognosis and poses major diagnostic and therapeutic challenges. A rat model of aGVHD after LTx has been developed, and a relative decrease in regulatory T (Treg) cells has been shown to be associated with this model. Interest has been expressed in the effects of different immunosuppressive agents on CD4+CD25+Foxp3+ Treg cell homeostasis. Rats with aGVHD after LTx were treated with tacrolimus (FK506), rapamycin (RAPA), or no immunosuppressive drug. Those that received RAPA survived longer (91.4 + or - 8.1 days) than those in the FK506 group (62.3 + or - 13.4 days) or the control group (22.9 + or - 1.2 days). Flow cytometry analysis showed that Treg cells, as a percentage of peripheral blood mononuclear cells (PBMCs), were more abundant in the RAPA group (6.8% + or - 0.8%) than in the FK506 group (1.7% + or - 0.4%) or the control group (2.0% + or - 0.4%). Immunohistochemistry demonstrated more Foxp3+ staining of intestinal cells in the RAPA group than in the FK506 group or the control group. In conclusion, the reduced mortality induced by RAPA in a rat model of aGVHD after LTx was associated with higher percentages of CD4+CD25+Foxp3+ Treg cells in PBMCs in blood and tissues than those occurring after the administration of FK506.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1527-6473
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
357-63
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| pubmed:meshHeading |
pubmed-meshheading:20209637-Animals,
pubmed-meshheading:20209637-Antigens, CD4,
pubmed-meshheading:20209637-Biopsy,
pubmed-meshheading:20209637-Disease Models, Animal,
pubmed-meshheading:20209637-Female,
pubmed-meshheading:20209637-Forkhead Transcription Factors,
pubmed-meshheading:20209637-Graft vs Host Disease,
pubmed-meshheading:20209637-Homeostasis,
pubmed-meshheading:20209637-Immune System,
pubmed-meshheading:20209637-Immunosuppressive Agents,
pubmed-meshheading:20209637-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:20209637-Liver Transplantation,
pubmed-meshheading:20209637-Male,
pubmed-meshheading:20209637-Rats,
pubmed-meshheading:20209637-Rats, Inbred Lew,
pubmed-meshheading:20209637-Sirolimus,
pubmed-meshheading:20209637-Skin,
pubmed-meshheading:20209637-T-Lymphocytes, Regulatory,
pubmed-meshheading:20209637-Tacrolimus
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| pubmed:year |
2010
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| pubmed:articleTitle |
Rapamycin and tacrolimus differentially modulate acute graft-versus-host disease in rats after liver transplantation.
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| pubmed:affiliation |
Department of Hepatobiliary and Pancreatic Surgery, Key Laboratory of Combined Multiorgan Transplantation (Ministry of Public Health), First Affiliated Hospital, Hangzhou, People's Republic of China.
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| pubmed:publicationType |
Journal Article
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