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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-3-29
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pubmed:abstractText |
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus. We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 x 10(-9)). TSLP is overexpressed in esophageal biopsies from individuals with EoE compared with unaffected individuals, whereas WDR36 expression is unaltered between the two groups. These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:AboniaJ PabloJP,
pubmed-author:AcevesSeemaS,
pubmed-author:AnnaiahKiranK,
pubmed-author:BlanchardCarineC,
pubmed-author:Brown-WhitehornTerriT,
pubmed-author:ChiavacciRosetta MRM,
pubmed-author:CianferoniAntonellaA,
pubmed-author:CollinsMargaret HMH,
pubmed-author:FrackeltonEdwardE,
pubmed-author:FranciosiJames PJP,
pubmed-author:GlessnerJosephJ,
pubmed-author:GoberLauraL,
pubmed-author:GrantStruan F ASF,
pubmed-author:HakonarsonHakonH,
pubmed-author:KellyThomasT,
pubmed-author:KimCeciliaC,
pubmed-author:LiacourasChrisC,
pubmed-author:MartinLisa JLJ,
pubmed-author:PutnamPhil EPE,
pubmed-author:RothenbergMarc EME,
pubmed-author:SherrillJoseph DJD,
pubmed-author:SleimanPatrick M APM,
pubmed-author:SpergelJonathan MJM,
pubmed-author:VermaRituR
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-91
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pubmed:dateRevised |
2011-4-8
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pubmed:meshHeading |
pubmed-meshheading:20208534-Child,
pubmed-meshheading:20208534-Chromosomes, Human, Pair 5,
pubmed-meshheading:20208534-Cytokines,
pubmed-meshheading:20208534-Eosinophils,
pubmed-meshheading:20208534-Esophagitis,
pubmed-meshheading:20208534-Eye Proteins,
pubmed-meshheading:20208534-Genome-Wide Association Study,
pubmed-meshheading:20208534-Humans,
pubmed-meshheading:20208534-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Common variants at 5q22 associate with pediatric eosinophilic esophagitis.
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pubmed:affiliation |
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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