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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-5-28
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pubmed:abstractText |
Cardiovascular responses to high-dose (0.100 IE kg-1 h-1) and low-dose insulin infusion (0.005-0.01 IE kg-1 h-1) were examined in eight hyperglycaemic, resting type I diabetics. Mean blood glucose dropped from 15.9 to 7.1 mmol l-1 and from 14.4 to 12.6 mmol l-1, respectively, during 1 h. Blood pressure and heart rate did not change. There were no significant changes in absolute or relative left ventricular volumes, the 95% confidence interval (CI) for the difference between the doses in left ventricular ejection fraction was -6 to 8%. Calf blood volume increased on high-dose insulin (p = 0.05, CI for the difference over low-dose insulin 0.0 to 4.6 ml 100 ml-1 tissue). Blood flow increased with 1.6 ml 100 ml-1 tissue min-1 with high-dose insulin and with 0.6 ml 100 ml-1 tissue min-1 with low-dose (CI for the difference -0.5 to 3.4). Noradrenaline increases were small and there was no difference between the doses (p = 0.47).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-5513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2020834-Adult,
pubmed-meshheading:2020834-Blood Flow Velocity,
pubmed-meshheading:2020834-Blood Glucose,
pubmed-meshheading:2020834-Blood Pressure,
pubmed-meshheading:2020834-Blood Volume,
pubmed-meshheading:2020834-Cardiac Output,
pubmed-meshheading:2020834-Cardiovascular System,
pubmed-meshheading:2020834-Diabetes Mellitus, Type 1,
pubmed-meshheading:2020834-Female,
pubmed-meshheading:2020834-Heart Rate,
pubmed-meshheading:2020834-Humans,
pubmed-meshheading:2020834-Insulin,
pubmed-meshheading:2020834-Male,
pubmed-meshheading:2020834-Stroke Volume
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pubmed:year |
1991
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pubmed:articleTitle |
Acute cardiovascular effects of insulin in hyperglycaemic type I diabetics.
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pubmed:affiliation |
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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