Source:http://linkedlifedata.com/resource/pubmed/id/20207982
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
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| pubmed:dateCreated |
2010-5-14
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| pubmed:abstractText |
Posttransplantation non-Hodgkin lymphoma is a life-threatening complication after transplantation. Although pharmacologically suppressed adaptive immunity plays a major role in its development, the role of innate immunity in posttransplantation lymphoma is unknown. We assessed the 158 V/F polymorphism in the Fc-gamma receptor 3A gene (FCGR3A), killer cell immunoglobulin-like receptor (KIR) genotype, KIR ligand status, and a single nucleotide polymorphism affecting the production of interferon-gamma (IFN-gamma; +874 A/T) in 236 patients with posttransplantation lymphoma reported to the Collaborative Transplant Study. In addition, polymorphisms in the interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) genes previously associated with lymphoma development were also typed. Using a split-cohort approach, gene/allele frequency was related to the 5-year patient survival after the diagnosis of lymphoma and compared with 100 control solid organ transplant recipients. FCGR3A and KIR genotype significantly influenced survival after diagnosis of posttransplantation lymphoma: the hazard of dying was reduced in homozygous carriers of the high-affinity V allele (hazard ratio 0.49, 95% confidence interval 0.29-0.82, P = .006), whereas carrying a genotype including KIR2DL2/KIR2DS2 increased the risk of dying (hazard ratio 1.49, 95% confidence interval 1.07-2.05, P = .02). KIR ligands and cytokine polymorphisms had no effect on survival. None of the genetic loci analyzed emerged as risk factors for lymphoma development.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/FCGR3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/KIR2DS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR3DL2
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1528-0020
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
13
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| pubmed:volume |
115
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3960-5
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| pubmed:meshHeading |
pubmed-meshheading:20207982-Adolescent,
pubmed-meshheading:20207982-Adult,
pubmed-meshheading:20207982-Aged,
pubmed-meshheading:20207982-Child,
pubmed-meshheading:20207982-Child, Preschool,
pubmed-meshheading:20207982-Cohort Studies,
pubmed-meshheading:20207982-Female,
pubmed-meshheading:20207982-Genotype,
pubmed-meshheading:20207982-Heart Transplantation,
pubmed-meshheading:20207982-Humans,
pubmed-meshheading:20207982-Interferon-gamma,
pubmed-meshheading:20207982-Kidney Transplantation,
pubmed-meshheading:20207982-Killer Cells, Natural,
pubmed-meshheading:20207982-Liver Transplantation,
pubmed-meshheading:20207982-Lymphoma, Non-Hodgkin,
pubmed-meshheading:20207982-Male,
pubmed-meshheading:20207982-Middle Aged,
pubmed-meshheading:20207982-Polymerase Chain Reaction,
pubmed-meshheading:20207982-Polymorphism, Single Nucleotide,
pubmed-meshheading:20207982-Receptors, IgG,
pubmed-meshheading:20207982-Receptors, KIR,
pubmed-meshheading:20207982-Receptors, KIR3DL2,
pubmed-meshheading:20207982-Survival Rate,
pubmed-meshheading:20207982-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.
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| pubmed:affiliation |
Immunobiology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland. sternm@uhbs.ch
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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