| pubmed-article:20207817 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20207817 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:20207817 | lifeskim:mentions | umls-concept:C0030011 | lld:lifeskim |
| pubmed-article:20207817 | lifeskim:mentions | umls-concept:C0244104 | lld:lifeskim |
| pubmed-article:20207817 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:20207817 | lifeskim:mentions | umls-concept:C0679932 | lld:lifeskim |
| pubmed-article:20207817 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:20207817 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:20207817 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20207817 | pubmed:dateCreated | 2010-5-5 | lld:pubmed |
| pubmed-article:20207817 | pubmed:abstractText | Carbon 13 nuclear magnetic resonance (NMR) isotopomer analysis was used to measure the rates of oxidation of long-chain fatty acids, ketones, and pyruvate to determine the minimum pyruvate concentration ([pyruvate]) needed to suppress oxidation of these alternative substrates. Substrate mixtures were chosen to represent either the fed or fasted state. At physiological [pyruvate], fatty acids and ketones supplied the overwhelming majority of acetyl-CoA. Under conditions mimicking the fed state, 3 mM pyruvate provided approximately 80% of acetyl-CoA, but under fasting conditions 6 mM pyruvate contributed only 33% of acetyl-CoA. Higher [pyruvate], 10-25 mM, was associated with transient reduced cardiac output, but overall hemodynamic performance was unchanged after equilibration. These observations suggested that 3-6 mM pyruvate in the coronary arteries would be an appropriate target for studies with hyperpolarized [1-(13)C]pyruvate. However, the metabolic products of 3 mM hyperpolarized [1-(13)C]pyruvate could not be detected in the isolated heart during perfusion with a physiological mixture of substrates including 3% albumin. In the presence of albumin even at high concentrations of pyruvate, 20 mM, hyperpolarized H(13)CO(3)(-) could be detected only in the absence of competing substrates. Highly purified albumin (but not albumin from plasma) substantially reduced the longitudinal relaxation time of [1-(13)C]pyruvate. In conclusion, studies of cardiac metabolism using hyperpolarized [1-(13)C]pyruvate are sensitive to the effects of competing substrates on pyruvate oxidation. | lld:pubmed |
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| pubmed-article:20207817 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20207817 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207817 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20207817 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20207817 | pubmed:month | May | lld:pubmed |
| pubmed-article:20207817 | pubmed:issn | 1522-1539 | lld:pubmed |
| pubmed-article:20207817 | pubmed:author | pubmed-author:SherryA... | lld:pubmed |
| pubmed-article:20207817 | pubmed:author | pubmed-author:MalloyCraig... | lld:pubmed |
| pubmed-article:20207817 | pubmed:author | pubmed-author:MerrittMatthe... | lld:pubmed |
| pubmed-article:20207817 | pubmed:author | pubmed-author:MorenoKarlos... | lld:pubmed |
| pubmed-article:20207817 | pubmed:author | pubmed-author:SabelhausScot... | lld:pubmed |
| pubmed-article:20207817 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20207817 | pubmed:volume | 298 | lld:pubmed |
| pubmed-article:20207817 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20207817 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20207817 | pubmed:pagination | H1556-64 | lld:pubmed |
| pubmed-article:20207817 | pubmed:dateRevised | 2011-9-27 | lld:pubmed |
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| pubmed-article:20207817 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20207817 | pubmed:articleTitle | Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate. | lld:pubmed |
