| pubmed-article:20207552 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C0427965 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C1418931 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C1419291 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C0279223 | lld:lifeskim |
| pubmed-article:20207552 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:20207552 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20207552 | pubmed:dateCreated | 2010-3-15 | lld:pubmed |
| pubmed-article:20207552 | pubmed:abstractText | This study aimed to determine the effect of sub-lethal challenge with Photodynamic Antimicrobial Chemotherapy (PACT) on the susceptibility of clinical Staphylococcus aureus and Pseudomonas aeruginosa isolates to both PACT and a range of antibiotics used in the treatment of infection caused by these bacteria. Clinical S. aureus and P. aeruginosa isolates were exposed to sub-lethal PACT with meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP) and methylene blue (MB) over a 72 h period. After exposure, susceptibility of surviving organisms to a range of antibiotics was determined and compared with the susceptibility of an untreated control. Surviving bacteria were also exposed to previously lethal photosensitizer-light combinations, to determine if susceptibility to PACT was affected by sub-lethal exposure. Exposure to sub-lethal PACT did not decrease susceptibility to antibiotics with the minimum inhibitory concentrations for 95% and 100% of P. aeruginosa and S. aureus isolates, respectively, within two doubling dilutions of the MIC of the untreated control. Similarly, habituation with sub-lethal PACT did not reduce susceptibility of P. aeruginosa isolates to PACT levels previously determined as lethal. A reduction in susceptibility to PACT following habituation was apparent for two S. aureus isolates with MB and for 1 S. aureus isolate with TMP. However, for two of these three isolates, the log reduction for habituated cells was still greater than 4 log(10). PACT remains an attractive potential treatment for infection caused by these bacteria. | lld:pubmed |
| pubmed-article:20207552 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20207552 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207552 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20207552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207552 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20207552 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20207552 | pubmed:issn | 1873-2682 | lld:pubmed |
| pubmed-article:20207552 | pubmed:author | pubmed-author:TunneyMichael... | lld:pubmed |
| pubmed-article:20207552 | pubmed:author | pubmed-author:DonnellyRyan... | lld:pubmed |
| pubmed-article:20207552 | pubmed:author | pubmed-author:CassidyCorona... | lld:pubmed |
| pubmed-article:20207552 | pubmed:copyrightInfo | Copyright 2010 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:20207552 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20207552 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:20207552 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:20207552 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20207552 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20207552 | pubmed:pagination | 62-6 | lld:pubmed |
| pubmed-article:20207552 | pubmed:meshHeading | pubmed-meshheading:20207552... | lld:pubmed |
| pubmed-article:20207552 | pubmed:meshHeading | pubmed-meshheading:20207552... | lld:pubmed |
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| pubmed-article:20207552 | pubmed:meshHeading | pubmed-meshheading:20207552... | lld:pubmed |
| pubmed-article:20207552 | pubmed:meshHeading | pubmed-meshheading:20207552... | lld:pubmed |
| pubmed-article:20207552 | pubmed:meshHeading | pubmed-meshheading:20207552... | lld:pubmed |
| pubmed-article:20207552 | pubmed:meshHeading | pubmed-meshheading:20207552... | lld:pubmed |
| pubmed-article:20207552 | pubmed:meshHeading | pubmed-meshheading:20207552... | lld:pubmed |
| pubmed-article:20207552 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20207552 | pubmed:articleTitle | Effect of sub-lethal challenge with Photodynamic Antimicrobial Chemotherapy (PACT) on the antibiotic susceptibility of clinical bacterial isolates. | lld:pubmed |
| pubmed-article:20207552 | pubmed:affiliation | School of Pharmacy, Queens University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK. | lld:pubmed |
| pubmed-article:20207552 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20207552 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
