| pubmed-article:20207226 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20207226 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
| pubmed-article:20207226 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:20207226 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20207226 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:20207226 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:20207226 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:20207226 | lifeskim:mentions | umls-concept:C1851476 | lld:lifeskim |
| pubmed-article:20207226 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20207226 | pubmed:dateCreated | 2010-3-8 | lld:pubmed |
| pubmed-article:20207226 | pubmed:abstractText | During a screen for humoral factors that promote cardiomyocyte differentiation from embryonic stem cells (ESCs), we found marked elevation of granulocyte colony-stimulating factor receptor (G-CSFR) mRNA in developing cardiomyocytes. We confirmed that both G-CSFR and G-CSF were specifically expressed in embryonic mouse heart at the midgestational stage, and expression levels were maintained throughout embryogenesis. Intrauterine G-CSF administration induced embryonic cardiomyocyte proliferation and caused hyperplasia. In contrast, approximately 50% of csf3r(-/-) mice died during late embryogenesis because of the thinning of atrioventricular walls. ESC-derived developing cardiomyocytes also strongly expressed G-CSFR. When extrinsic G-CSF was administered to the ESC- and human iPSC-derived cardiomyocytes, it markedly augmented their proliferation. Moreover, G-CSF-neutralizing antibody inhibited their proliferation. These findings indicated that G-CSF is critically involved in cardiomyocyte proliferation during development, and may be used to boost the yield of cardiomyocytes from ESCs for their potential application to regenerative medicine. | lld:pubmed |
| pubmed-article:20207226 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20207226 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207226 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20207226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207226 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20207226 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20207226 | pubmed:issn | 1875-9777 | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:OgawaSatoshiS | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:ChenHaoH | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:TanakaTomofum... | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:KoshimizuUich... | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:FukudaKeiichi... | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:HattoriFumiyu... | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:YaeKojiroK | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:SekiTomohisaT | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:YuasaShinsuke... | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:OnizukaTakesh... | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:ShimojiKenich... | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:OhnoYoheiY | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:HaraMieM | lld:pubmed |
| pubmed-article:20207226 | pubmed:author | pubmed-author:EgasgiraToruT | lld:pubmed |
| pubmed-article:20207226 | pubmed:copyrightInfo | 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20207226 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20207226 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:20207226 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:20207226 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20207226 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20207226 | pubmed:pagination | 227-37 | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:meshHeading | pubmed-meshheading:20207226... | lld:pubmed |
| pubmed-article:20207226 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20207226 | pubmed:articleTitle | G-CSF promotes the proliferation of developing cardiomyocytes in vivo and in derivation from ESCs and iPSCs. | lld:pubmed |
| pubmed-article:20207226 | pubmed:affiliation | Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160-8582, Japan. | lld:pubmed |
| pubmed-article:20207226 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20207226 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20207226 | lld:pubmed |
