Source:http://linkedlifedata.com/resource/pubmed/id/20205168
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0005938,
umls-concept:C0025266,
umls-concept:C0042333,
umls-concept:C0086982,
umls-concept:C0243127,
umls-concept:C0262950,
umls-concept:C0332281,
umls-concept:C0443331,
umls-concept:C0699794,
umls-concept:C1336645,
umls-concept:C1367028,
umls-concept:C1412836,
umls-concept:C1420805,
umls-concept:C1710303
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| pubmed:issue |
8
|
| pubmed:dateCreated |
2010-8-11
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| pubmed:abstractText |
The aim of this study was to determine if single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG influence bone turnover and bone mineral density (BMD) in men. Pairwise tag SNPs (r(2) > or = 0.8) were selected for RANKL, RANK, and OPG and their 10-kb flanking regions. Selected tag SNPs plus five SNPs near RANKL and OPG, associated with BMD in published genome-wide association studies (GWAS), were genotyped in 2653 men aged 40 to 79 years of age recruited for participation in a population-based study of male aging, the European Male Ageing Study (EMAS). N-terminal propeptide of type I procollagen (PINP) and C-terminal cross-linked telopeptide of type I collagen (CTX-I) serum levels were measured in all men. BMD at the calcaneus was estimated by quantitative ultrasound (QUS) in all men. Lumbar spine and total-hip areal BMD (BMD(a)) was measured by dual-energy X-ray absorptiometry (DXA) in a subsample of 620 men. Multiple OPG, RANK, and RANKL SNPs were associated with bone turnover markers. We also identified a number of SNPs associated with BMD, including rs2073618 in OPG and rs9594759 near RANKL. The minor allele of rs2073618 (C) was associated with higher levels of both PINP (beta = 1.83, p = .004) and CTX-I (beta = 17.59, p = 4.74 x 10(-4)), and lower lumbar spine BMD(a) (beta = -0.02, p = .026). The minor allele of rs9594759 (C) was associated with lower PINP (beta = -1.84, p = .003) and CTX-I (beta = -27.02, p = 6.06 x 10(-8)) and higher ultrasound BMD at the calcaneus (beta = 0.01, p = .037). Our findings suggest that genetic variation in the RANKL/RANK/OPG signaling pathway influences bone turnover and BMD in European men.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1523-4681
|
| pubmed:author |
pubmed-author:AdamsJudith EJE,
pubmed-author:BartfaiGyorgyG,
pubmed-author:BoonenStevenS,
pubmed-author:BorghsHermanH,
pubmed-author:CasanuevaFelipeF,
pubmed-author:EMAS Study Group,
pubmed-author:FinnJoseph DJD,
pubmed-author:FortiGianniG,
pubmed-author:GiwercmanAleksanderA,
pubmed-author:HanThang STS,
pubmed-author:HollidayKate LKL,
pubmed-author:HuhtaniemiIlpo TIT,
pubmed-author:KulaKrzysztofK,
pubmed-author:LeanMichael EME,
pubmed-author:O'NeillTerence WTW,
pubmed-author:PendletonNeilN,
pubmed-author:PunabMargusM,
pubmed-author:PyeStephen RSR,
pubmed-author:RoshandelDelnazD,
pubmed-author:SilmanAlan JAJ,
pubmed-author:ThomsonWendyW,
pubmed-author:VanderschuerenDirkD,
pubmed-author:WardKate AKA,
pubmed-author:WuFrederick CFC
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1830-8
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| pubmed:meshHeading |
pubmed-meshheading:20205168-Absorptiometry, Photon,
pubmed-meshheading:20205168-Adult,
pubmed-meshheading:20205168-Aged,
pubmed-meshheading:20205168-Bone Density,
pubmed-meshheading:20205168-Bone Remodeling,
pubmed-meshheading:20205168-Bone and Bones,
pubmed-meshheading:20205168-Europe,
pubmed-meshheading:20205168-Genetic Association Studies,
pubmed-meshheading:20205168-Genetic Markers,
pubmed-meshheading:20205168-Genetic Variation,
pubmed-meshheading:20205168-Genotype,
pubmed-meshheading:20205168-Humans,
pubmed-meshheading:20205168-Male,
pubmed-meshheading:20205168-Middle Aged,
pubmed-meshheading:20205168-Osteoprotegerin,
pubmed-meshheading:20205168-Polymorphism, Single Nucleotide,
pubmed-meshheading:20205168-RANK Ligand,
pubmed-meshheading:20205168-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:20205168-Signal Transduction
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men.
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| pubmed:affiliation |
Arthritis Research UK, Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|