rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
2010-4-14
|
pubmed:abstractText |
Sorafenib is a novel oral anticancer agent targeting signal transduction and angiogenic pathways through inhibitory effects against MAP kinases and vascular endothelial growth factor receptor-2. The objectives of this neoadjuvant phase II-trial in patients with advanced epithelial ovarian cancer were to assess the activity and tolerability of the combination therapy of carboplatin/paclitaxel with multi-target tyrosine kinase inhibitor sorafenib.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1432-0843
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
66
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
203-7
|
pubmed:meshHeading |
pubmed-meshheading:20204367-Adult,
pubmed-meshheading:20204367-Aged,
pubmed-meshheading:20204367-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:20204367-Benzenesulfonates,
pubmed-meshheading:20204367-Carboplatin,
pubmed-meshheading:20204367-Early Termination of Clinical Trials,
pubmed-meshheading:20204367-Female,
pubmed-meshheading:20204367-Humans,
pubmed-meshheading:20204367-Middle Aged,
pubmed-meshheading:20204367-Neoadjuvant Therapy,
pubmed-meshheading:20204367-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:20204367-Ovarian Neoplasms,
pubmed-meshheading:20204367-Paclitaxel,
pubmed-meshheading:20204367-Pyridines
|
pubmed:year |
2010
|
pubmed:articleTitle |
Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer.
|
pubmed:affiliation |
Department of Gynecology and Obstetrics, Center for Integrated Oncology, Bonn University Medical Center, University Hospital of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II
|