Source:http://linkedlifedata.com/resource/pubmed/id/20204274
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2010-3-5
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pubmed:abstractText |
Proteoglycans are ubiquitous components of the extracellular matrix and cell surface, and may mediate tumor progression and metastasis. The aim of this study was to evaluate the expression of syndecan-1 and versican in epithelial ovarian cancer. We immunohistochemically evaluated the expression of syndecan-1 and versican in 111 patients with epithelial ovarian cancer, and analyzed the correlation of this expression with various observed clinicopathological features, including patient outcome. There is a significant correlation between primary and metastatic sites with respect to syndecan-1 and versican expression. Epithelial syndecan-1 expression was significantly lower in patients with advanced disease. Epithelial versican expression was significantly higher in patients with early disease, especially in clear cell adenocarcinoma patients. Stromal syndecan-1 and versican expression was significantly higher in patients with advanced disease. Multivariate analysis showed that negative epithelial syndecan-1 expression was an independent prognostic factor for progression-free survival. Stromal syndecan-1 and versican co-expression was of borderline significance for progression-free and overall survival. Loss of epithelial syndecan-1 expression and induction of stromal syndecan-1 and versican expression may be associated with tumor progression in epithelial ovarian cancer. Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/SDC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecan-1,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/VCAN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Versicans
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1791-2431
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
917-25
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20204274-Disease-Free Survival,
pubmed-meshheading:20204274-Female,
pubmed-meshheading:20204274-Humans,
pubmed-meshheading:20204274-Immunohistochemistry,
pubmed-meshheading:20204274-Kaplan-Meier Estimate,
pubmed-meshheading:20204274-Middle Aged,
pubmed-meshheading:20204274-Neoplasm Staging,
pubmed-meshheading:20204274-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:20204274-Ovarian Neoplasms,
pubmed-meshheading:20204274-Prognosis,
pubmed-meshheading:20204274-Syndecan-1,
pubmed-meshheading:20204274-Tumor Markers, Biological,
pubmed-meshheading:20204274-Versicans
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pubmed:year |
2010
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pubmed:articleTitle |
Clinical significance of syndecan-1 and versican expression in human epithelial ovarian cancer.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
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pubmed:publicationType |
Journal Article
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