Linked Life Data

20201875

Source:http://linkedlifedata.com/resource/pubmed/id/20201875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-3-5
pubmed:abstractText
This chapter focuses on evidence linking socio-economic status (SES) to "downstream" peripheral biology. Drawing on the concept of allostatic load, we examine evidence linking lower SES with greater cumulative physiological toll on multiple major biological regulatory systems over the life course. We begin by reviewing evidence linking lower SES to poorer trajectories of aging in multiple, individual physiological systems, followed by evidence of the resulting cumulative, overall burdens of physiological dysregulation seen among those of lower SES. The role of cumulative physiological dysregulation in mediating SES gradients in morbidity and mortality is then examined. We conclude with discussion of the question of interactions between SES (and other such environmental factors) and genetic endowment, and their potential consequences for patterns of physiological activity--an area of research that appears poised to contribute significantly to our understanding of how social conditions "get under the skin" to affect health and aging.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-39
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Socio-economic differentials in peripheral biology: cumulative allostatic load.
pubmed:affiliation
Division of Geriatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1687, USA. tseeman@mednet.ucla.edu
pubmed:publicationType
Journal Article, Review