Linked Life Data

20199214

Source:http://linkedlifedata.com/resource/pubmed/id/20199214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-3-4
pubmed:abstractText
Electronic brachytherapy systems are being developed that can deliver X rays of varying energy depending on the material of a secondary target. A copper target produces characteristic 8 keV X rays. Our aim was to determine whether 8 keV X rays might deliver greater biological effectiveness than megavoltage photons. Cells of the U251 human glioma cell line were used to compare the biological effects of 8 keV X rays and (60)Co gamma rays in terms of relative biological effectiveness (RBE), oxygen enhancement ratio (OER), and DNA damage. The RBE at 50% and 10% survival was 2.6 and 1.9, respectively. At 50% survival, the OER for cells treated with 8 keV X rays was 1.6 compared with 3.0 for (60)Co gamma rays. The numbers of H2AX foci per Gy after treatment with 8 keV X rays and (60)Co gamma rays were similar; however, the size of the foci generated at 8 keV was significantly larger, possibly indicating more complex DNA damage. The mean area of H2AX foci generated by 8 keV X rays was 0.785 microm(2) (95% CI: 0.756-0.814) compared with 0.491 microm(2) (95% CI: 0.462-0.520) for (60)Co gamma rays (P < 0.0001). Characteristic 8 keV X rays produce two to three times the biological effectiveness of megavoltage photons, with a radiobiological profile similar to higher-LET radiations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1938-5404
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
173
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
290-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Characteristic 8 keV X rays possess radiobiological properties of higher-LET radiation.
pubmed:affiliation
Wayne State University, Detroit, Michigan 48201-2013, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't