Linked Life Data

20197196

Source:http://linkedlifedata.com/resource/pubmed/id/20197196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-24
pubmed:abstractText
A silent polymorphism (1359 G/A) of the cannabinoid receptor gene was reported as a common polymorphism in white populations. The aim of our study was to investigate the influence of this polymorphism (G1359A) of cannabinoid receptor gene on obesity, insulin resistance, and adipocytokines in women with obesity. A population of 290 women was analyzed. Indirect calorimetry, tetrapolar electrical bioimpedance, blood pressure measurement, serial assessment of nutritional intake with 3-day written food records, and biochemical analysis were performed. One hundred fifty-nine patients (54.8%) had the genotype G1359G (wild-type group), and 131 (45.2%) patients had G1359A (116 patients, 40.0%) or A1359A (15 patients, 5.2%) (mutant-type group). Triglycerides (122.3 ± 65.9 vs 107.2 ± 44.8 mg/dL, P < .05), insulin (15.8 ± 9.4 vs 13.6 ± 6.9 mUI/L, P < .05), and homeostasis model assessment values (3.85 ± 2.2 vs 3.33 ± 1.9, P < .05) were higher in the wild-type group than the mutant-type group. High-density lipoprotein cholesterol levels (56.8 ± 24.1 vs 58.3 ± 13.9 mg/dL, P < .05) were higher in the mutant-type group than the wild-type group. The novel finding of this study is the association of the mutant-type group G1359A and A1359A with a better cardiovascular profile (triglyceride, high-density lipoprotein cholesterol, insulin, and homeostasis model assessment levels) than the wild-type group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1532-8600
pubmed:author
pubmed:copyrightInfo
© 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
272-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Influence of G1359A polymorphism of the cannabinoid receptor gene on anthropometric parameters and insulin resistance in women with obesity.
pubmed:affiliation
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Simancas 47130, Valladolid, Spain. dadluis@yahoo.es
pubmed:publicationType
Journal Article