Linked Life Data

20197144

Source:http://linkedlifedata.com/resource/pubmed/id/20197144

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2010-4-13
pubmed:abstractText
The impact of the 7-valent pneumococcal conjugate vaccine (PCV7) on the pneumococcal flora has been mostly studied without evaluating multiple colonization and the mechanism(s) leading to serotype replacement. These issues are addressed here, while assessing the effect of a single PCV7 dose. A group of children received one PCV7 dose just after nasopharyngeal sampling, with the control receiving no vaccine and both groups being sampled again a month later. Up to 10 pneumococcal isolates were recovered per colonized child-1224 isolates were serotyped and representative ones characterized by pulsed-field gel electrophoresis. In vaccinated children, serotype replacement between vaccine (VT) and non-vaccine (NVT) types occurred in single and multiple carriers, and VTs were less prone to be de novo acquired. NVT unmasking was only detected in the vaccinated group. One month after vaccination with a single dose, PCV7 prevents VT de novo acquisition and promotes NVT unmasking.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-2518
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3445-52
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Impact of a single dose of the 7-valent pneumococcal conjugate vaccine on colonization.
pubmed:affiliation
Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa (ITQB/UNL), Rua da Quinta Grande, 6, Oeiras 2780-156, Portugal. nfrazao@itqb.unl.pt
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't