pubmed:abstractText |
Investigation of collagenase and gelatinase inhibitory natural components afforded two isoflavonoids. Two isoflavonoids, tectorigenin-7-O-?-D-glucoside (1) and luteolin-7-O-?-D-glucuronopyranoside (2), were isolated from ethyl acetate fraction of Viola patrinii fermentation extracts (VPFE). Of these, compounds 1 and 2 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1.5 ?M, and compound 2 showed gelatinases A and B inhibitory activity (IC(50)) at 0.3 ?M and 0.8 ?M, respectively.
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