| pubmed-article:20194691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C0008051 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C0029923 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C0332464 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C1519279 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C0015272 | lld:lifeskim |
| pubmed-article:20194691 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:20194691 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20194691 | pubmed:dateCreated | 2010-4-20 | lld:pubmed |
| pubmed-article:20194691 | pubmed:abstractText | Heterosexual transmission is the primary route by which women acquire human immunodeficiency virus (HIV)/AIDS. Thus, development of woman-controlled topical microbicides for prevention of sexual transmission of HIV is urgently needed. Here we report that 3-hydroxyphthalic anhydride-modified chicken ovalbumin (HP-OVA) exhibits potent antiviral activity against a broad spectrum of human immunodeficiency virus type 1 (HIV-1) isolates with different genotypes and biotypes. Its antiviral activity is correlated with the percentages of the chemically modified and unmodified lysines and arginines in OVA. HP-OVA inhibits HIV-1 fusion and entry through multiple mechanisms of action, including (i) blocking gp120 binding to CD4 and (ii) interfering with gp41 six-helix bundle formation. Because of the widespread availability and established safety profile of OVA, HP-OVA has good potential to be developed as an effective, safe, and affordable microbicide for prevention of HIV sexual transmission. | lld:pubmed |
| pubmed-article:20194691 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20194691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20194691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20194691 | pubmed:month | May | lld:pubmed |
| pubmed-article:20194691 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:JooFF | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:SícJJ | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:LuHongH | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:HuLilyL | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:JiangShiboS | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:AnXiuliX | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:LiuShuwenS | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:GuoXinhuaX | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:TanSuiyiS | lld:pubmed |
| pubmed-article:20194691 | pubmed:author | pubmed-author:PanChungenC | lld:pubmed |
| pubmed-article:20194691 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20194691 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:20194691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20194691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20194691 | pubmed:pagination | 1700-11 | lld:pubmed |
| pubmed-article:20194691 | pubmed:dateRevised | 2010-11-2 | lld:pubmed |
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| pubmed-article:20194691 | pubmed:meshHeading | pubmed-meshheading:20194691... | lld:pubmed |
| pubmed-article:20194691 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20194691 | pubmed:articleTitle | 3-hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1. | lld:pubmed |
| pubmed-article:20194691 | pubmed:affiliation | School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China. | lld:pubmed |
| pubmed-article:20194691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20194691 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20194691 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20194691 | lld:pubmed |
